摘要
目的分析血清总胆汁酸测定在肝病诊断中的应用。方法选择该院于2018年1—11月收治的400例肝病患者及同期于该院接受健康检查的75名健康体检者作为研究对象。给予所有受检者血清总胆汁酸检测及天冬氨酸氨基转移酶、丙氨酸氨基转移酶检测。结果急性病毒性肝炎组、慢性活动性肝炎组、肝硬化组、乙型肝炎组、原发性肝癌组血清总胆汁酸、天冬氨酸氨基转移酶、丙氨酸氨基转移酶水平均高于对照组(P<0.05),其中,急性病毒性肝炎组患者三项指标水平最高,血清总胆汁酸(186.27±14.93)μmol/L、天冬氨酸氨基转移酶(762.03±59.15)U/L、丙氨酸氨基转移酶(831.95±57.22)U/L。血清总胆汁酸检测诊断急性病毒性肝炎准确率100.00%、慢性活动性肝炎94.29%(χ^2=0.49,P=0.59)、肝硬化97.75%(χ^2=0.38,P=0.89)、乙型肝炎90.63%(χ^2=0.49,P=0.53)、原发性肝癌100.00%(χ^2=0.79,P=0.41),与综合诊断对比差异无统计学意义(P>0.05)。结论血清总胆汁酸用于肝病诊断,诊断准确性较高。
Objective To analyze the application of serum total bile acid determination in the diagnosis of liver diseases.Methods A total of 400 patients with liver disease who were admitted to our hospital from January to November 2018 and 75 healthy subjects who underwent health examinations in our hospital were selected as subjects.Serum total bile acid detection and aspartate aminotransferase and alanine aminotransferase assays were administered to all subjects.Results The levels of serum total bile acid,aspartate aminotransferase and alanine aminotransferase in acute viral hepatitis group,chronic active hepatitis group,liver cirrhosis group,hepatitis B group and primary liver cancer group were higher than those in serum of the control group(P<0.05),among which,the acute viral hepatitis group had the highest level of three indicators,serum total bile acid(186.27±14.93)μmol/L,aspartate aminotransferase(762.03±59.15)U/L,alanine aminotransferase(831.95±57.22)U/L.The detection rate of serum total bile acid was 100.00%for acute viral hepatitis,94.29%for chronic active hepatitis(χ^2=0.49,P=0.59),97.75%for liver cirrhosis(χ^2=0.38,P=0.89),and hepatitis B 90.63%(χ^2=0.49,P=0.53),primary liver cancer 100.00%(χ^2=0.79,P=0.41),and the difference was not significant compared with the comprehensive diagnosis(P>0.05).Conclusion Serum total bile acid is used for the diagnosis of liver disease with high diagnostic accuracy.
作者
李松鹏
徐丽萍
景红艳
LI Song-peng;XU Li-ping;JING Hong-yan(Department of Clinical Laboratory,Kunming Third People's Hospital,Kunming,Yunnan Province,650041 China;Department of Clinical Laboratory,Jinning District People's Hospital,Kunming,Yunnan Province,650600 China)
出处
《中外医疗》
2019年第19期189-192,共4页
China & Foreign Medical Treatment
关键词
血清总胆汁酸
肝病
诊断
Serum total bile acid
Liver disease
Diagnosis
