摘要
口服脊髓灰质炎减毒活疫苗(oral poliomyelitis attenuated live vaccine,OPV)和脊髓灰质炎灭活疫苗(inactivated poliomyelitis vaccine,IPV)的实施在消灭脊髓灰质炎(poliomyelitis)中发挥了重要作用,但仍存在疫苗相关麻痹型脊髓灰质炎(vaccine-associated paralytic poliomyelitis,VAPP)和疫苗衍生脊髓灰质炎病毒(vaccine-derived poliovirus,VDPV)病例的发生。为避免该风险,中国自2016年5月1日起停用三价OPV(trivalent oral poliomyelitis attenuated live vaccine,t OPV),改用二价脊髓灰质炎减毒活疫苗(bivalent oral poliomyelitis attenuated live vaccine,bOPV),并将IPV纳入国家免疫规划(national immunization program,NIP),即采用IPV-OPV-OPV-OPV序贯免疫程序进行接种,不仅能降低VAPP的发生,还能维持较高的肠道黏膜免疫力。本文就国内不同IPV-OPV序贯免疫程序的应用、免疫效果及安全性作一综述。
The implementation of oral live attenuated poliomyelitis vaccine (OPV)and inactivated poliomyelitis vaccine (IPV)plays an important role in the eradication of polio. However,the cases of vaccine-associated paralytic poliomyelitis (VAPP) and vaccine-derived poliovirus (VDPV) are still exist. In order to avoid the risk,Chinese government has stopped the application of trivalent oral poliomyelitis attenuated live vaccine (tOPV)and switched to that of bivalent oral poliomyelitis attenuated live vaccine (bOPV)since May 1,2016,and has included IPV into the National Immunization Program(NIP). Therefore,the IPV-OPV-OPV-OPV sequential immunization schedule has been adopted in China,which not only reduces the incidence of VAPP,but also maintains high intestinal mucosal immunity. In this paper,the application, immune effect and safety of various IPV-OPV sequential immunization schedules in China are reviewed.
作者
邓鹏飞
费怡
杨天
肖绍坦
DENG Peng-fei;FEI Yi;YANG Tian;XIAO Shao-tan(Center for Diseases Control and Prevention,Fudan University Pudong Institute of Preventive Medicine,Shanghai Pudong,Shanghai 200136,China)
出处
《中国生物制品学杂志》
CAS
CSCD
2019年第7期823-827,共5页
Chinese Journal of Biologicals
基金
国家科技重大专项(2018ZX10713-001-008)
浦东新区卫生和计划生育委员会科技项目(PW2016A-10)
关键词
脊髓灰质炎疫苗
序贯接种
免疫效果
安全性
Poliomyelitis vaccine
Sequential immunization
Immune effect
Safety
