摘要
晚发型抑郁症(LOD)特指首次发病于60岁以后的原发性抑郁症。认知功能损害是增加LOD治疗难度的主要原因之一,在抗抑郁基础上改善认知功能损害是有效治疗LOD的关键。本文从"脉络丛(CP)衰老-叶酸脑转运-海马神经发生"这一新视角,探讨了LOD认知功能损害的机制,结合补肾法抗衰老和抗抑郁的效应及机制,认为运用补肾法治疗LOD能充分体现针对性和整体性相结合的治疗特色和优势。以认知功能修复为切入点,今后应深入开展有关补肾法发挥其整体有效抗LOD效应的作用靶点和机制的临床及基础研究,这对于LOD临床疗效的整体提高具有重要的意义。
Late-onset depression(LOD) refers to primary depression after age 60.Cognitive impairment is one of the main reasons to increase the difficulty of LOD treatment. Improving cognitive impairment on the basis of anti-depression is the key to effective treatment of LOD. From a new perspective of "choroid plexus(CP) aging-folate′s brain transport-hippocampal neurogenesis", the mechanisms of cognitive impairment in LOD were discussed in the paper. Combining with anti-aging and antidepressant effects, Shen-tonifying therapy in LOD could fully embody the therapeutic characteristic and advantage of the pertinence and integrality. From the cognitive function recovery, the further clinical and basic researches on the targets and mechanisms of Shen-tonifying therapy for LOD should be carried out in the future, which is of great significance for improving the comprehensive therapeutic effect of LOD.
作者
牛婕
严灿
吴丽丽
NIU Jie;YAN Can;WU Li-li(School of Basic Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2019年第7期868-871,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(No.81774102)
关键词
晚发型抑郁症
认知功能
脉络丛
叶酸
海马神经发生
补肾法
late-onset depression
cognitive function
choroid plexus
folate
hippocampal neurogenesis
Shen-tonifying therapy
