摘要
目的:观察解郁丸联合盐酸舍曲林治疗青少年抑郁症的临床疗效。方法:选择2023年1月—2024年1月玉林市退役军人医院收治的80例首发的青少年抑郁症患者,按随机数字表法分为对照组和试验组各40例。对照组口服盐酸舍曲林片治疗,试验组在对照组基础上加服解郁丸治疗。2组均治疗4周,比较2组临床疗效,以及治疗前后神经递质[5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)]相对功率、汉密尔顿抑郁量表(HAMD)评分及副反应量表(TESS)评分。结果:试验组总有效率为95.00%(38/40),对照组为77.50%(31/40),2组比较,差异有统计学意义(P<0.05)。治疗后,2组HAMD评分均较治疗前降低(P<0.05),且试验组HAMD评分低于对照组(P<0.05)。治疗后,2组5-HT、NE、DA相对功率均较治疗前升高(P<0.05),且试验组上述3项指标水平均高于对照组(P<0.05)。治疗期间,试验组不良反应发生率为2.50%(1/40),对照组为17.50%(7/40),组间比较,差异有统计学意义(P<0.05)。结论:解郁丸联合盐酸舍曲林治疗青少年抑郁症可提高临床疗效,显著改善患者抑郁症状及神经递质相对效能,减少不良反应的发生。
Objective:To observe the clinical effect of Jieyu Pills combined with Sertraline Hydrochloride in treating adolescent depression.Methods:A total of 80 first-onset adolescent depression patients admitted to Yulin Veterans Hospital from January 2023 to January 2024 were selected and divided into the control group and the trial group using the random number table method,with 40 cases in each group.The control group received oral Sertraline Hydrochloride Tablets,while the trial group received Jieyu Pills in addition to Sertraline Hydrochloride.Both groups were treated for four weeks.The clinical effects,relative power of neurotransmitters[5-hydroxytryptamine(5-HT),norepinephrine(NE),dopamine(DA)],scores of Hamilton Depression Scale(HAMD),and scores of Treatment Emergent Symptom Scale(TESS)were compared between the two groups before and after treatment.Results:The total effective rate was 95.00%(38/40)in the trial group and 77.50%(31/40)in the control group,the difference being significant between the two groups(P<0.05).After treatment,HAMD scores were decreased in both groups when compared with those before treatment(P<0.05),with the trial group showing lower HAMD scores than the control group(P<0.05).After treatment,the relative power of 5-HT,NE,and DA were increased significantly in both groups(P<0.05),with higher relative power observed in the trial group compared to the control group(P<0.05).The incidence of adverse reactions during treatment was 2.50%(1/40)in the trial group and 17.50%(7/40)in the control group,the difference being significant(P<0.05).Conclusion:Jieyu Pills combined with Sertraline Hydrochloride improves clinical effect in treating adolescent depression,significantly alleviates depressive symptoms,enhances neurotransmitter relative power,and reduces adverse reactions.
作者
刘丽雅
吕媛新
梁桂华
潘锋
罗定祥
翚红星
LIU Liya;LYU Yuanxin;LIANG Guihua;PAN Feng;LUO Dingxiang;HUI Hongxing(Yulin Veterans Hospital,Yulin Guangxi 537000,China)
出处
《新中医》
2025年第14期101-104,共4页
New Chinese Medicine
基金
广西玉林市科技计划项目(玉市科202235024)。
关键词
青少年抑郁症
解郁丸
盐酸舍曲林
神经递质相对功率
汉密尔顿抑郁量表
Adolescent depression
Jieyu Pills
Sertraline Hydrochloride
Relative power of neurotransmitters
Hamilton Depression Scale
