摘要
目的探讨妊娠晚期孕产妇B族链球菌(GBS)感染情况及其对妊娠结局的影响。方法选择2016年1月1日-2018年12月3 l日间在本院进行常规产科检查并分娩的单胎孕产妇635例为研究对象。根据GBS检测结果分为感染组(65例)和对照组(570例),比较两组孕产妇GBS感染状况及不良妊娠结局情况。结果 635例孕产妇中GBS检测结果阳性65例,阳性率为10.23%(65/635)。不同年龄、孕次和产次间GBS阳性率差异无统计学意义(分别χ^2=3.769,P=0.082;χ^2=1.217,P=0.270;χ^=7.617,P=0.060)。妊娠期糖尿病、妊娠期高血压孕产妇GBS阳性率高于非妊娠期糖尿病、妊娠期高血压孕产妇,组间差异有统计学意义(分别χ^2=13.416,P<0.001;χ^2=7.901,P=0.008)。GBS感染组孕产后出血、胎儿窘迫、新生儿感染发病率高于对照组,两组间差异有统计学意义(分别χ^2=4.211,P=0.044;χ^2=7.425,P=0.003、χ^2=11.627,P=0.001);GBS感染组胎膜早破和早产发病率高于对照组,但两组间差异无统计学意义(分别χ^2=0.508,P=0.476;χ^2=0.923,P=0.337)。结论妊娠晚期孕产妇GBS的感染率较高,妊娠期糖尿病和妊娠期高血压是妊娠晚期孕产妇GBS感染的危险因素。GBS感染能增加产后出血、胎儿窘迫、新生儿感染发病率,针对GBS感染孕产妇进行抗生素类有效治疗能改善孕妇不良妊娠结局。
Objective To explore the infection status of group B Streptococcus(GBS) in perinatal pregnant women and analyze the adverse pregnancy outcomes. Methods 635 cases were selected who were single birth pregnant women, divided all study objects into infected group(65 cases) and control group(570 cases) according to the result of GBS testing. We compared the infection status of GBS and adverse pregnancy outcomes between the two groups. Results The GBS was tested positive in 65 of 635 third trimester of pregnant women, with the infection rate of 10.23%. There were differences between two groups of age and number of abortions and times of delivery(respectively χ^2=3.769,P=0.082;χ^2=1.217,P=0.270;χ^2=7.617,P=0.060). The positive rate of GBS in pregnant women with gestational diabetes mellitus and gestational hypertension was higher than those who were no gestational diabetes mellitus and gestational hypertension(respectively χ^2=13.416,P=0.000;χ^2=7.901,P=0.008). The incidence of postpartum hemorrhage, fetal distress and neonatal infection in the GBS infection group was higher than that in the control group(respectively χ^2=4.211,P=0.044;χ^2=7.425,P=0.003、χ^2=11.627,P=0.001). The incidence of premature rupture of membranes and premature birth in GBS infection group was higher than that in control group, but there was no significant difference(respectively χ^2=0.508,P=0.476;χ^2=0.923,P=0.337). Conclusion The infection rate of GBS in late pregnancy is higher. Gestational diabetes mellitus and gestational hypertension are the risk factors of GBS infection in third trimester of pregnancy women. GBS infection may increase the incidence of postpartum hemorrhage, fetal distress and neonatal infection. Effective antibiotic treatment for GBS infected pregnant women improve the pregnancy outcomes.
作者
叶登花
古伟玲
赖燕华
YE Denghua;GU WeiHng;LAI Yanhua(Dprartment of Obsterics and Gynecology, The People's Hospital of Dongyuan Cuntry, Heyuan 517000, China)
出处
《广州医药》
2019年第4期35-37,73,共4页
Guangzhou Medical Journal
关键词
妊娠晚期
B族链球菌
妊娠结局
Third trimester of pregnancy
Group B Streptococcus
Pregnancy outcome
