摘要
目的:观察和探讨银屑病患者血清白介素17(IL-17),白介素21(IL-21)及白介素22(IL-22)水平与病情的相关性。方法:选择2016年10月~2018年4月收治的银屑病患者72例作为实验组,另选择同期健康体检者72例作为对照组,分别检测两组血清中TNF-α、IL-17、IL-21及IL-22水平,探讨三者与银屑病的相关性。结果:银屑病患者血清TNF-α、IL-17、IL-21及IL-22水平高于对照组,差异均有统计学意义(P<0.05)。银屑病患者血清IL-17、IL-21及IL-22水平相关性分析结果表明,血清TNF-α水平与IL-17、IL-21及IL-22水平呈明显正相关(r=0.7138,P<0.05;r=0.7026,P<0.05;r=0.7658,P<0.05),血清IL-17水平与IL-21及IL-22水平亦呈明显正相关。结论:银屑病患者血清IL-17、IL-21及IL-22水平均显著性的增高,均可用于银屑病的辅助诊断。
Objective:To observe and explore the correlation between serum interleukin-17(IL-17)、IL-21(IL-21)and IL-22(IL-22)in patients with psoriasis.Methods:From October 2016 to April 2018,72 cases of patients with psoriasis as experimental group,another choice over the same period health physical examination of 72 cases as control group,two groups of serum TNF-αwas detected in alpha,IL–17、IL-21 and IL-22 levels,explore the correlation between the three and psoriasis.Results:Serum TNF-αconditioning,IL-17、IL-21 and IL-22 levels in patients with psoriasis were higher than those in the control group,and the difference was statistically significant(P<0.05).The results of the correlation analysis of serum IL-17、IL-21 and IL-22 levels in patients with psoriasis showed that serum TNF-αlevel was significantly positively correlated with IL-17、IL-21 and IL-22 levels(r=0.7138,P<0.05).r=0.7026,P<0.05;r=0.7658,P<0.05).Serum IL-17 level was also positively correlated with IL-21 and IL-22 levels.Conclusion:Serum IL-17、IL-21 and IL-22 levels of patients with psoriasis increased significantly,which could be used for the auxiliary diagnosis of psoriasis.
作者
辛德辉
张雁来
周可人
赵晓秋
XIN De-hui;ZHANG Yan-lai;ZHOU Ke-ren;ZHAO Xiao-qiu(The First Affiliated Hospital of Jiamusi University,Heilongjiang Jiamusi 154002;The Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《微量元素与健康研究》
CAS
2019年第4期13-15,共3页
Studies of Trace Elements and Health
基金
黑龙江省卫生计生委科研项目(编号:2016-289)
