摘要
细辛醚和β-细辛醚是天南星科多年生草本植物石菖蒲的主要活性成分。近年研究发现,α-细辛醚和β-细辛醚除具有抗肿瘤、杀虫抑菌、止咳平喘、保护神经元、抗癫痫、抗抑郁等作用外,其在心脑血管疾病方面具有较好的药理活性。本文通过查阅近年国内外相关文献,从α-细辛醚和β-细辛醚保护心肌和血管细胞(包括血管内皮细胞和血管平滑肌细胞),抗血栓形成,降血脂,改善血管功能等方面进行综述,为进一步深入挖掘上述成分在心脑血管疾病中的作用,探索相关的机制提供参考。
Alpha-asarone and β-asarone are the main active ingredients of the herbaceous perennial plant of Araceae. In recent years, it has been found that α-asarone and β-asarone possess good effects in preventing cardio-cerebrovascular diseases besides anti-cancer, insecticide and bacteriostasis, antitussive and antiasthmatic, neuroprotection, anti-epileptic anti-depression and other effects.This article summarizes the relevant literatures both at home and abroad in recent years, provides an overview of their cardio-cerebrovascular related activities from their protective effects on cardiomyocytes, vascular cells(endothelial cell and vascular smooth muscle cell),antithrombotic, hypolipidemic, vascular tension and so on. This review provides references to further explore the roles and mechanisms of the above components in cardio-cerebrovascular diseases.
作者
刘家欣
王丹
刘森
万进东
王沛坚
LIU Jia-xin;WANG Dan;LIU Sen;WAN Jin-dong;WANG Pei-jian(Department of Cardiology,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan,610500,China;Key Laboratory of Aging and Vascular Homeostasis,Sichuan Provincial Universities,Chengdu,Sichuan,610500,China)
出处
《现代生物医学进展》
CAS
2019年第9期1797-1800,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81400289)
四川省杰出青年学术技术带头资助计划(2016JQ0032)
四川省教育厅科研创新团队项目(18TD0030)
四川省医学会科研项目(S15022)
成都医学院科研创新团队项目(CYTD16-01)
关键词
细辛醚
Β-细辛醚
心脑血管疾病
α-asarone
β-asarone
Cardio-cerebrovascular disease
