摘要
目的 探讨非瓣膜性房颤病人血清中血小板衍生生长因子家族(PDGFs)及内皮素-1(ET-1)的表达及其与中医辨证分型的相关性。方法 对91例非瓣膜性房颤病人进行中医辨证分型,用酶联免疫吸附法(ELISA)测定病人血清PDGF-AA、PDGF-BB、PDGF-DD及ET-1的表达。结果 非瓣膜性房颤组病人PDGF-AA、PDGF-BB、PDGF-DD及ET-1的表达水平明显高于窦性心律对照组(P<0.05)。心脉瘀阻证血清PDGF-AA、PDGF-BB、PDGF-DD及ET-1的表达水平明显高于气阴两虚证、心阳不振证及痰浊阻滞证(P<0.05或P<0.01)。气阴两虚证、心阳不振证及痰浊阻滞证间上述参数比较差异均无统计学意义(P>0.05)。结论 心脉瘀阻证房颤病人心肌纤维化反应更为显著,PDGFs及ET-1的表达水平可能为房颤心脉瘀阻证病人的辨证分型提供一定的客观依据。
Objective To investigate the relationship between the expression of platelet-derived growth factor family (PDGFs),endothelin-1 (ET-1) and syndrome differentiation of traditional Chinese medicine (TCM) in patients with non-valvular atrial fibrillation (NVAF). Methods Ninety-one patients with NVAF were diagnosed by TCM syndrome differentiation.The expressions of serum PDGF-AA,PDGF-BB,PDGF-DD,and ET-1 were measured by enzyme-linked immunosorbent assay (ELISA). Results The levels of serum PDGF-AA,PDGF-BB,PDGF-DD,and ET-1 in patients with NVAF were significantly higher than those in the sinus rhythm group ( P <0.05).The levels of serum PDGF-AA,PDGF-BB,PDGF-DD,and ET-1 in patients with blood stasis syndrome were significantly higher than those in patients with qi and yin deficiency syndrome,heart yang deficiency syndrome,and turbid phlegm syndrome ( P <0.05).There was no significant difference in the levels of serum PDGF-AA,PDGF-BB,PDGF-DD,and ET-1 among qi and yin deficiency syndrome,heart yang deficiency syndrome,and turbid phlegm syndrome ( P >0.05). Conclusion Myocardial fibrosis is more significant in NVAF patients with blood stasis syndrome.The expression levels of PDGFs and ET-1 may provide some objective basis for the syndrome differentiation in NVAF patients with blood stasis syndrome.
作者
付明朝
刘强
FU Mingzhao;LIU Qiang(Zhuji Hospital of Traditional Chinese Medicine, Zhuji 311800,Zhejiang,China)
出处
《中西医结合心脑血管病杂志》
2019年第11期1671-1674,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
浙江省中医药管理局科研基金项目(No.2016ZA070)
关键词
房颤
血小板衍生生长因子
内皮素-1
心肌纤维化
中医证型
atrial fibrillation
platelet-derived growth factor
endothelin-1
myocardial fibrosis
traditional Chinese medicine syndrome
