摘要
4-羟基吲哚、环氧氯丙烷在氢氧化钠的乙醇溶液中反应生成中间体1-(1H-吲哚-4-氧基)-3-氯-2-丙醇,然后中间体与异丙胺反应,合成出了目标产物吲哚洛尔{1-(1H-吲哚-4-氧基)-3-[(1-甲基乙基)氨基]-2-丙醇}。通过1HNMR、13CNMR、IR对合成的吲哚洛尔进行表征,结果表明与理论结构一致。
The intermediate 1-(1H-indole-4-oxy)-3-chloro-2-propanol was formed by the reaction of 4-hydroxyindole and epichlorohydrin in the alcohol solution of sodium hydroxide,and then the intermediate reacted with isopropylamine to synthesis indololol (1-(1H-indole-4-oxy)-3-[(1-methyl ethyl) amino]-2-propanol.The indolol was characterized by 1H NMR, 13 C NMR,IR,and the results showed that it was consistent with the theoretical structure.
作者
蒋雨
卢大斌
王诗婷
熊艳萍
张玉鹏
夏芳
李艳
JIANG Yu;LU Dabin;WANG Shiting;XIONG Yanping;ZHANG Yupeng;XIA Fang;LI Yan(School of Nuclear Technology and Chemistry & Biology,Hubei University of Science and Technology,Xianning 437100,China;E’nan High School,Xianning 437100,China)
出处
《化工科技》
CAS
2019年第3期19-22,共4页
Science & Technology in Chemical Industry
基金
国家级大学生创新训练项目(201810927010)
关键词
4-羟基吲哚
吲哚洛尔
合成
表征
4-Hydroxyindole
Indolol
Synthesis
Characterization
