摘要
以L-色氨酸为起始原料,经过甲酯化、Pictet-Spengler反应、结晶诱导非对称转化(CIAT)、脱盐酸化等步骤,得到5个1-芳基四氢-β-咔啉-3-羧酸甲酯化合物。目标产物通过重结晶、柱层析等方法纯化,其结构经元素分析、IR、1 H NMR、13C NMR、NOE等进行表征。
Five 1-aryl-tetrahydro-β-carboline-3-carboxylic methyl ethers were synthesized by using L-tryptophan as the starting material via a four-step process including methyl-esterification,Pictet-Spengler reaction,crystallization-induced asymmetric transformation（CIAT） and deacidification.The compounds were purified by recrystallization and column chromatography.Their structures were characterized by elemental analysis,IR,1H NMR,13C NMR,NOE techniques.
出处
《化学世界》
CAS
CSCD
北大核心
2013年第1期30-34,共5页
Chemical World
基金
陕西省教育厅重点实验室项目(2010JS056)
咸阳市科技计划项目(2010K10-06)
