摘要
目的探讨D-二聚体(D-D)、红细胞分布宽度(RDW)在颅内静脉窦血栓诊断及其预后判断中的价值。方法选择2013年1月至2017年5月接受治疗的42例颅内静脉窦血栓形成(CVST)患者为观察组;另选同期接受治疗的42例脑梗死患者为对照组。对两组患者治疗前后血常规指标及D-D、RDW水平进行比较,采用Logistic回归法分析CVST及预后的影响因素。结果观察组D-D、RDW水平显著高于对照组,平均红细胞体积(MCV)水平低于对照组(P<0.05,P<0.01),而血红蛋白(Hb)、血小板计数(PLT)、血小板平均体积(MPV)、凝血酶原时间(PT)以及活化部分凝血酶原时间(APTT)两组间比较差异无统计学意义(P>0.05)。Logistic回归分析显示,D-D、RDW水平升高均为CVST的危险因素(P<0.05)。经过3个月的随访,观察组患者中27例预后良好。预后优良组D-D、RDW水平显著低于预后不良组(P<0.01),两组MCV比较差异无统计学意义(P>0.05)。Logistic回归分析显示,D-D、RDW水平升高均为CVST患者预后不佳的危险因素(P<0.05)。结论CVST患者的D-D、RDW水平异常升高,得到有效治疗后可显著下降,二者均为CVST及其预后的影响因素。
Objective To investigate the clinical value of D-dimer( D-D) and red cell distribution width ( RDW) in the diagnosis and prognosis prediction of cerebral venous sinus thrombosis( CVST).Methods Forty-two CVST patients treated from January 2013 to May 2017 were selected as observation group, and 42 patients with cerebral infarction treated in the same period were selected as control group.The blood routine indexes, D-D and RDW levels were compared between two groups before and after treatment,and the influencing factors of CVST and prognosis were analyzed by Logistic regression method.Results The levels of D-D, RDW, mean corpuscular volume ( MCV) in observation group were significantly higher than those in control group ( P < 0.05, P < 0.01), however, there were no statistical differences in hemoglobin ( Hb),platelet count ( PLT), mean platelet volume ( MPV), prothrombin time ( PT) and activated partial thrombin time ( APTT) between two groups ( all P > 0.05).Logistic regression analysis showed that high D-D and RDW were risk factors for CVST( P < 0.05).After 3-month follow-up,there were 27 patients with good prognosis in observation group.The levels of D-D and RDW in patients with good prognosis were significantly lower than those in the patients with poor prognosis ( P < 0.01).There was no significant difference in MCV between two groups ( P > 0.05).Logistic regression analysis showed that high D-D and RDW were risk factors for poor prognosis of CVST( P < 0.05).Conclusions The levels of D-D and RDW can increase abnormally in CVST patients,but obviously decrease after effective treatment.Both of them are the risk factors of CVST and its prognosis.
作者
赵振林
赵思蓉
刘康峰
肖华
ZHAO Zhen-lin;ZHAO Si-rong;LIU Kang-feng;XIAO Hua(Department of Neurosurgery,Guangzhou Huadu District People's Hospital,Guangzhou,Guangdong 510800,China)
出处
《中国临床研究》
CAS
2019年第5期631-633,共3页
Chinese Journal of Clinical Research
基金
广州市花都区卫生局审批项目(16HDWS-046)~~
