摘要
目的探讨湿润烧伤膏防治乳腺癌改良根治术后放射治疗所致放射性皮肤损伤的临床疗效。方法按照随机数表法将2014年8月至2018年8月沂水县人民医院及临沂市第三人民医院收治的拟采用放射治疗的乳腺癌改良根治术后患者随机分为观察组(60例)与对照组(60例),其中观察组患者于放射治疗后在放射部位预防性应用湿润烧伤膏,对照组患者放射治疗后不采取任何防护措施,对比观察两组患者放射部位皮肤损伤程度、皮肤损伤出现时间及放射治疗中断情况等。结果放射治疗20、40 Gy及疗程结束后,观察组患者皮肤损伤程度均明显低于对照组,两组对比,P均<0.01,差异具有统计学意义;观察组患者皮肤损伤出现时间为(30.80±1.40)d,明显晚于对照组患者皮肤损伤出现时间(16.60±1.80)d,两组对比,P<0.01,差异具有统计学意义;治疗过程中,观察组患者中无1例患者中断治疗,对照组患者中14例患者中断治疗,两组对比,P<0.01,差异具有统计学意义。结论湿润烧伤膏可有效减轻乳腺癌改良根治术后放射治疗所致放射性皮肤损伤的损伤程度,延缓皮肤损伤出现时间,疗效显著,且操作简便,值得临床推广应用。
Objective To explore the clinical efficacy of MEBO in the prevention and treatment of radiationinduced skin damage following the modified radical mastectomy.Methods One hundred and twenty patients admitted into Yishui People’s Hospital and Liny in Third People’s Hospital between August 2014 and August 2018 for radiation therapy after the modified radical mastectomy were divided into an observation group(60 patients)and a control group(60 patients)according to the random number table.In the observation group,MEBO was applied prophylactically onto the radiation sites while in the control group no any management was given onto the radiation sites.The condition of skin damage,appearance time of skin damage and discontinuation of radiation therapy were observed and compared between the two groups.Results After the completion of 20 Gy and 40 Gy,and at the end of the treatment course,the skin damage condition in the observation group was all markedly better than that in the control group,and the differences were statistically significant,all P<0.01.The appearance time of skin damage in the observation group was(30.80±1.40)d,which was obviously later than the(16.60±1.80)d in the control group,and the difference was also statistically significant,P<0.01.During the treatment course,no patient discontinued the treatment in the observation group while there were 14 patients discontinued the treatment in the control group,between which the comparison showed statistically significant difference,P<0.01.Conclusion MEBO can effectively relieve the radiation-induced skin damage condition following the modified radical mastectomy,delay the appearance time of skin damage.Given its easy-and-simple operation and significant clinical efficacy,MEBO deserves to be applied in clinical practice.
作者
高丽
武霞
Gao Li;Wu Xia(Surgery Department,Yishui People's Hospital,Linyi City,Shandong 276400,China;Department of Oncology of Linyi Third People's Hospital,Linyi City,Shandong 276023,China)
出处
《中国烧伤创疡杂志》
2019年第3期170-173,共4页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
湿润烧伤膏
乳腺癌
改良根治术
放射治疗
放射性皮肤损伤
预防
疗效
MEBO
Breast cancer
Modified radical mastectomy
Radiation therapy
Radiation-induced skin damage
Prevention
Clinical efficacy
