摘要
为了在本科阶段加强对学生科研能力的培养,我们结合自身的科研工作和有机化学最新科研成果,介绍一个面向大学高年级本科生的综合性有机化学实验——新型靛红衍生的对亚甲基苯醌的合成与结构表征。以靛红为起始原料,经过脱水缩合、氨基上Boc保护基两步反应,结合柱层析、萃取等多种分离手段,最终得到目标化合物。实验中采用TLC法跟踪实验的反应进程,并利用熔点测定、红外光谱和核磁共振谱图等表征手段确定了目标化合物的结构。
In order to strengthen students scientific research ability in the undergraduate stage, combined our own research work and the latest scientific research results of organic chemistry, a comprehensive organic chemistry experiment for senior undergraduates, the synthesis and characterization of a novel para-quinone methides derived from isatin, was introduced. Starting from isatins, after two-step reaction of dehydration condensation and introducing Boc protecting group on the amino group, combined chromatography, extraction and other separation methods, the target compound was finally obtained. TLC was used to track the progress of the experiment. The structure of the target compound was determined by melting point determination, infrared spectroscopy and nuclear magnetic resonance spectroscopy.
作者
梁国娟
周静
LIANG Guo-juan;ZHOU Jing(College of Pharmacy, Chongqing Medical University, Chongqing 400010, China)
出处
《广州化工》
CAS
2019年第9期169-171,共3页
GuangZhou Chemical Industry
关键词
靛红衍生的对亚甲基苯醌
红外光谱
核磁共振谱
缩合反应
氨基上Boc保护基
para-quinone methides derived from isatins
infrared spectrum
nuclear magnetic resonance spectroscopy
dehydration condensation
Boc protecting group on the amino group
