摘要
柴胡和黄芩是临床上常见的中药配伍,是《伤寒论》中最具代表意义的药对配伍之一,作为经典药对广泛运用于呼吸系统、消化系统、心血管系统和神经系统疾病的复方治疗中。研究发现,柴胡黄芩药对配伍可以提高柴胡皂苷和黄芩苷的溶出量,这可能该是药对配伍药效增强的物质基础。现代药理研究表明,柴黄药对具有缓解肝损伤、抗肝纤维化、抗病毒、解热抗炎、治疗肝癌、利胆和抗癫痫等作用。本文从配伍后主要药效成分溶出研究和药理作用等方面对柴胡黄芩药对的文献进行综述,以期为其深入开发提供参考。
Radix Bupleuri and Radix Scutellariae are common herb pair of traditional Chinese medicine in clinical practice, and is also one of the most representative compatibility of drugs in the Treatise on Febrile Diseases. As a classic medicine suits, they are widely used in the treatment of respiratory system, digestive system, cardiovascular system and nervous system diseases. It was found that the compatibility of Radix Bupleuri with Radix Scutellariae improved the dissolution of Saikoside and Baicalin, which may be the material basis for enhancing the efficacy of this medicine suits.Modern pharmacological studies have shown that Chaihuang herb pair has the functions of relieving liver injury, antiliver fibrosis, anti-virus, antipyretic and anti-inflammation, treating liver cancer, choleretic action and anti-epilepsy.This paper reviews the literatures on Chaihuang herb pair from the aspects of dissolution of main medicinal ingredients and pharmacological action after compatibility, so as to provide references for its further development.
作者
张程亮
兰露露
任秀华
刘东
Zhang Chengliang;Lan Lulu;Ren Xiuhua;Liu Dong(Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan 430030, China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2019年第1期33-37,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委面上项目(81670521):基于核受体研究IL-33在免疫性肝损伤中下调羧酸酯酶的机制
负责人:张程亮
关键词
柴胡
黄芩
药效成分
药理作用
Radix Bupleuri
Radix Scutellariae
medicinal ingredients
pharmacological effect
