摘要
目的研究采用富血小板血浆治疗慢性难愈合伤口的价值和意义。方法从2017年10月～2018年8月来院治疗的慢性难愈合伤口患者中,通过随机数字表法抽取76例作为研究对象,并按照奇、偶数法的相关要求将其平均分为两组,其中单纯接受医用凡士林纱布治疗的38例患者设为对照组,在采用医用凡士林纱布治疗的同时加用富血小板血浆治疗的38例患者设为观察组,分析不同治疗方案对观察组和对照组患者治疗前后创口体积以及肉芽组织内VEGF(表皮细胞生长因子)含量、平均愈合时间的影响。结果治疗前观察组和对照组患者的创口体积以及肉芽组织内VEGF含量比较差异无统计学意义(P> 0.05);和对照组相比,治疗后21 d、42 d观察组患者创口体积明显变小,组间差异具有统计学意义(P<0.05),观察组患者治疗后42 d肉芽组织内VEGF含量、平均愈合时间更占优势(P <0.05)。结论将富血小板血浆方案用于慢性难愈合伤口治疗中,不仅提高伤口修复速度,还减少了局部损伤面积,增强治疗效果。
Objective To study the value and significance of platelet rich plasma therapy for chronic refractory wounds.Methods From October 2017 to August 2018 in our hospital,76 cases patients with chronic refractory wounds were selected as the research objects by the random number table method of extraction. According to the related requirements of odd and even number method,they were divided into two groups on average,including pure medical vaseline gauze treatment of 38 patients as control group,Medical Vaseline gauze combined with platelet-rich plasma therapy of 38 patients as observation group.To analyze the effects of different treatment schemes on wound volume and VEGF in granulation tissue(skin cell growth factor) content,the influence of the average healing time in observation group and control group before and after treatment in patients with chronic refractory wounds.Results In this study,the difference in wound volume and VEGF content in granulation tissue between the observation group and the control group before and after treatment was not statistically significant(P>0.05). The wound volume of patients in the observation group on 21 d and 42 d after treatment were respectively of patients in the control group on 21 d and 42 d after treatment better than those,showing statistically significant differences between the two groups(P<0.05).The observation group was more predominant in the content of vascular endothelial growth factor and the average healing time of granulation tissue 42 days after treatment(P<0.05).Conclusion The application of platelet-rich plasma therapy in the treatment of chronic refractory wounds not only improves the speed of wound repair,but also reduces the local injury area and increases the therapeutic effect.
作者
刘东海
LIU Dong-hai(Former People's Hospital,Jiangmen 529159,Guangdong,China)
出处
《中国处方药》
2019年第5期144-146,共3页
Journal of China Prescription Drug
关键词
慢性难愈合伤口
富血小板血浆
VEGF
疗效
Chronic refractory wounds
Platelet-rich plasma
Vascular endothelial growth factor
Efficacy
