摘要
目的探讨高频重复经颅磁刺激联合帕利哌酮治疗老年女性精神分裂症阴性症状患者的临床效果,并分析安全性。方法选择我院2016年1月～2017年11月期间收治的老年女性精神分裂症阴性症状患者,60例,按照随机数字表法,将患者分为对照组和观察组各30例。两组均采用帕利哌酮,观察组在此基础上联合高频重复经颅磁刺激,对照组给予伪刺激,治疗8周。评价患者症状改善情况、认知功能和不良反应。结果治疗8周后,观察组阴性症状、阳性症状、一般精神病理分和总分均低于对照组,差异有统计学意义(P<0.05);观察组干扰命名评分高于对照组(P<0.05);观察组总有效率高于对照组(P<0.05);两组不良反应发生率无差异(P>0.05)。结论针对老年女性精神分裂症阴性症状患者,在给予帕利哌酮治疗的同时联合高频rTMS,能够明显促进患者阴性症状和认知功能的改善,值得临床推广应用。
Objective To explore the clinical efficacy of high frequency repetitive transcranial magnetic stimulation combined with paliperidone in the treatment of senile schizophrenic negative symptoms. Methods A total of 60 elderly women with schizophrenia negative symptoms in our hospital from January 2016 to November 2017 were selected,were randomly divided into control group and observation group for 30 cases. Paliperidone was used in the two groups,and the observation group combined with high frequency repetitive transcranial magnetic stimulation,and the control group was given pseudo stimulation. Evaluated the patients’ symptoms improvement、cognitive function and adverse reactions. Results After 8 weeks of treatment,the negative symptoms,positive symptoms,general psychopathological points and total scores in the observation group was lower(P<0.05). The nomenclature scores of the observation group was higher(P<0.05). The total effective rate of the observation group was higher(P<0.05). There was no difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion For the elderly schizophrenic patients with negative symptoms,giving paliperidone treatment combined with high-frequency repetitive transcranial magnetic stimulation,could obviously promote the negative symptoms and cognitive function,worthy of clinical application.
作者
刘向阳
刘家梅
史建新
刘晶晶
LIU Xiangyang;LIU Jiamei;SHI Jianxin(Geriatric psychiatry, Zhumadian psychosis hospital, Zhumadian 463000, China)
出处
《国际精神病学杂志》
2019年第2期263-265,269,共4页
Journal Of International Psychiatry
关键词
帕利哌酮
高频重复经颅磁刺激
精神分裂症
阴性症状
Paliperidone
High frequency repetitive transcranial magnetic stimulation
Schizophrenia
Negative symptoms
