摘要
目的:探讨棕榈酸帕利哌酮注射液与帕利哌酮缓释片分别治疗精神分裂症的疗效及经济学价值。方法:选取2015年1月—2016年9月重庆市精神卫生中心收治的精神分裂症患者84例作为研究对象,以随机数字表法分为观察组40例和对照组44例。观察组患者给予棕榈酸帕利哌酮注射液治疗,对照组患者给予帕利哌酮缓释片治疗,两组均治疗12个月。于治疗前及治疗后第1、2、3、6、9、12月末,采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评定两组患者的疗效;比较两组患者不良反应发生情况的差异;采用药物经济学方法进行成本-效果分析。结果:治疗第9、12个月末,观察组患者的PANSS评分明显低于对照组,差异有极显著统计学意义(P<0.01);观察组患者的总有效率明显高于对照组,观察组患者的总费用及成本-效果比明显低于对照组,差异均有统计学意义(P<0.05);两组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:相比于帕利哌酮缓释片,棕榈酸帕利哌酮注射液治疗精神分裂症的1年期疗效显著,经济学价值高。
OBJECTIVE： To probe into the efficacy and economic value of palioprostone palmitme injec.tion and Paliperidone extended-release tablets in treatment of schizophrenia. METHODS： 84 patients with schizophrenia admitted into Chongqing Mental Health Center from Jan. 2015 to Sep. 2016 were selected and divided into observalion group （40 cases） and control group （44 cases） via the random number table. The observation group was treated with palioprostone palmitate injection, while the control group was given Paliperidone extended-release tablets, both groups had received a twelve-month treatment. The efficacy of two groups was evaluated l^y PANSS before treatment and at the 1st, 2nd, 3rd, 6th, 9th, 12th month after treatment; the incidence of adverse drug reactions of two groups was compared; and the cost-effect ratio （C/E） was analyzed with pharmacoeconomics methods. RESULTS： At the end of 9th and 12th month after treatment, the PANSS score of the observation group was significantly lower than that of the control group, with statistically significant difference （P 〈0.01 ） ; the total effective rate of the observation group was significantly higher than that of the control group, the total cost and C/E of the observation group was significantly lower than those of the control group, with statistically significant difference （P 〈 0. 05 ）; there was no statistical significance in incidence of adverse drug reactions between two groups （P 〉 0. 05）. CONCLUSIONS ： Compared with Paliperidone extended-release tablets, the efficacy of palioprostone palmitate injection in a one-year treatment of schizophrenia is remarkable, with higher economic value.
出处
《中国医院用药评价与分析》
2017年第6期792-795,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
帕利哌酮缓释片
棕榈酸帕利哌酮注射液
精神分裂症
疗效
卫生经济学
Paliperidone extended release tablets
Paliperidone palmitate injection
Schizophrenia
Efficacy
Health economics
