摘要
目的探讨行氟^(18)标记的脱氧葡萄糖(^(18)F-FDG)PET/CT与MRI在病理诊断明确的胰腺病变中的应用价值。资料与方法回顾性分析152例经病理明确诊断的胰腺病变患者的PET/CT及MRI结果,与病理结果对照,计算PET/CT及MRI诊断的敏感度、特异度、阳性预测值、阴性预测值及准确度。采用受试者工作特征(ROC)曲线计算PET/CT最大标准化摄取值(SUVmax)鉴别诊断良、恶性病变的阈值。比较PET/CT、MRI测量病变长径与病理诊断测量的差异及相关性。结果 152例胰腺病变患者中,106例恶性,46例良性,PET/CT的诊断敏感度、特异度、阳性预测值、阴性预测值及准确度分别为92.5%、63.0%、85.1%、76.3%及82.9%,MRI分别为85.8%、73.9%、88.3%、69.4%及82.2%。ROC曲线显示SUVmax区分良、恶性病变的阈值为3.25。PET/CT测量所得病灶长径与病理结果、MRI结果与病理结果差异均无统计学意义(P>0.05)。PET/CT测量所得病灶长径与病理结果(r=0.898,P=0.001)、MRI结果与病理结果(r=0.948,P=0.023)均呈正相关。结论 ^(18)F-FDG PET/CT与MRI相比在鉴别诊断胰腺良、恶性病变中具有较好的敏感度、阴性预测值及准确度,SUVmax及测量大小具有一定的参考价值。
Purpose To explore the application value of 18 F-fluorodeoxyglucose ( 18 F-FDG) PET/CT imaging in pancreatic lesions which are specifically diagnosed by pathology. Materials and Methods PET/CT and MRI results of 152 patients with pancreatic lesions which were specifically diagnosed by pathology were retrospectively analyzed. The results were compared with pathological results to calculate sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT and MRI diagnosis. ROC curve was taken to calculate the maximum standard uptake value (SUVmax) of PET/CT to identify threshold value of benign and malignant lesions. The difference of lesion diameter measured by PET/CT and MRI and pathology was compared, and their correlations were also analyzed. Results Among the 152 patients with pancreatic lesions, 106 were malignant and 46 were benign. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy diagnosed with PET/CT were 92.5%, 63.0%, 85.1%, 76.3% and 82.9%, respectively;and that of MRI were 85.8%, 73.9%, 88.3%, 69.4% and 82.2%, respectively. ROC curve indicated that threshold value in judging malignancy and benign was 3.25. There was no statistical significance regarding lesion diameter measured with PET/CT and pathological results and MRI results and pathological results (P>0.05). There was correlation between lesion diameter measured with PET/CT and pathological results (r=0.898, P=0.001) and MRI results and pathological results (r=0.948, P=0.023). Conclusion Compared with MRI, PET/CT is of better sensitivity, negative predictive value and accuracy in identifying and diagnosing benign and malignant pancreatic lesions and SUVmax and measured size are of certain reference value.
作者
王瑞民
何婷婷
关志伟
孙亚兵
徐白萱
WANG Ruimin;HE Tingting;GUAN Zhiwei;SUN Yabing;XU Baixuan(Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing 100853, China)
出处
《中国医学影像学杂志》
CSCD
北大核心
2019年第4期277-281,共5页
Chinese Journal of Medical Imaging
关键词
胰腺疾病
胰腺肿瘤
正电子发射断层显像术
体层摄影术
X
线计算机
磁共振成像
氟脱氧葡萄糖F18
敏感性与特异性
诊断
鉴别
Pancreatic diseases
Pancreatic neoplasms
Positron emission tomography/computed tomography
Tomography, X-ray computed
Magnetic resonance imaging
Fluorodeoxyglucose F18
Sensitivity and specificity
Diagnosis, differential
