摘要
目的:对在预防老年髋关节周围骨折下肢深静脉血栓形成中丹参川芎嗪联合低分子肝素的应用价值进行探讨,以期为进一步改善老年髋关节周围骨折患者预后提供参考。方法:将我院于2016年8月—2018年7月间接收的84例老年髋关节周围骨折患者纳入本次研究观察范围,采用抽签的方式将患者等分为对照组(42例)与观察组(42例),给予对照组患者单一低分子肝素治疗,给予观察组患者丹参川芎嗪联合低分子肝素治疗,对两种治疗方案下患者下肢深静脉血栓的形成情况进行对比,并观察患者治疗前后血红蛋白、血小板、血D-二聚体值及凝血指标的变化情况。结果:与对照组相比,在术后3个月内下肢深静脉血栓形成率上,观察组明显较低(P<0.05);治疗前两组血红蛋白、血小板及血D-二聚体均无明显差异(P>0.05),治疗后两组血红蛋白、血小板及血D-二聚体均明显下降(P<0.05),与同时期的对照组相比,观察组治疗后血红蛋白、血小板差异均不明显(P>0.05),血D-二聚体明显较低(P<0.05);治疗前后两组凝血指标均差异不明显(P>0.05)。结论:将丹参川芎嗪与低分子肝素联合应用于老年髋关节周围骨折患者的治疗中可有效预防其下肢深静脉血栓的形成,降低血D-二聚体值,对血小板、血红蛋白及凝血机制均无明显影响。
Objective: To investigate the application value of salvia miltiorrhiza combined with low molecular weight heparin (LMWH) in the prevention of deep venous thrombosis of lower extremity with periarticular fracture in elderly patients. In order to further improve the prognosis of the elderly patients with periarticular fractures. Methods: From August 2016 to July 2018, 84 elderly patients with perihip fracture were included in the study. The patients were divided into control group (42 cases) and observation group (42 cases) by drawing lots. The patients in the control group were treated with single low molecular weight heparin, and those in the observation group were treated with salvia miltiorrhiza and low molecular weight heparin. The changes of hemoglobin, platelet, blood D-dimer and coagulation index were observed before and after treatment. Results: Compared with the control group, the rate of deep vein thrombosis in the observation group was significantly lower than that in the control group within 3 months after operation (P<0.05). Before treatment, there was no significant difference in hemoglobin, platelet and blood D-dimer between the two groups (P>0.05). After treatment, hemoglobin, platelet and blood D-dimer in the two groups were significantly decreased (P<0.05), compared with the control group at the same period. Hemoglobin after treatment in the observation group, There was no significant difference in platelet (P>0.05), blood D-dimer (P<0.05), and no significant difference in coagulation indexes between the two groups before and after treatment (P>0.05). Conclusion: The combination of salvia miltiorrhiza ligustrazine and low molecular weight heparin can effectively prevent the formation of deep venous thrombosis in the lower extremities of the elderly patients with perihip fractures, reduce the blood D-dimer, and improve the platelet count. Hemoglobin and coagulation mechanism have no obvious influence, it is worth popularizing.
作者
杨媛媛
郭蕊
孟丽娟
YANG Yuan-yuan;GUO Rui;MENG Li-juan(Department of Orthopaedics, Luohe Hospital of Chinese Medicine, Luohe Henan 462000,China)
出处
《药品评价》
CAS
2019年第6期16-19,共4页
Drug Evaluation
基金
河南省教育厅资助项目
编号:2016-GH-205
关键词
老年
髋关节周围骨折
丹参川芎嗪
低分子肝素
下肢深静脉血栓
预防
Elderly
Perihip fFracture
Salvia Miltiorrhiza Ligustrazine
Low Molecular Weight Heparin
Deep vVein Thrombosis of Lower Extremity
Prevention
