摘要
目的探讨美沙拉嗪联合双歧三联活菌治疗溃疡性结肠炎的疗效及其对炎性因子的影响。方法选取2017年1月～2018年1月我院收治的溃疡性结肠炎患者80例,随机分为两组,每组各40例,两组患者均予常规对症治疗,同时两组均予美沙拉嗪缓释颗粒,观察组同时加用双歧三联活菌胶囊,治疗后比较两组患者治疗后的临床疗效,以及两组患者治疗前后TNF-α、IL-10水平的变化情况及两组患者治疗前后的临床症状积分变化情况。结果观察组治疗后的总有效率为95.00%,显著高于对照组的总有效率70.00%,两组疗效比较差异具有显著性(P<0.05)。治疗后,两组患者的炎性因子TNF-α、IL-10水平较治疗前显著降低(P<0.05)。且观察组患者治疗后的TNF-α、IL-10水平显著低于对照组(P<0.05)。观察组患者治疗后的临床症状积分为(2.56±0.85)分,与治疗前及对照组比较,差异有统计学意义(P<0.05)。结论美沙拉嗪联合双歧三联活菌治疗溃疡性结肠炎疗效确切,且可以抑制炎症反应,值得临床推广和应用。
Objective To investigate the efficacy of mesalazine combined with bifidobacteria in the treatment of ulcerative colitis and its effect on inflammatory factors. Methods 80 patients with ulcerative colitis admitted in our hospital from January 2017 to January 2018 were randomly divided into observation group and control group, with 40 cases in each group. Both groups were treated with conventional symptomatic treatment. All of them were treated with mesalazine sustained-release granules. The observation group was also treated with bifidobacteria capsules. The clinical effects after treatment, the changes of TNF-α and IL-10 levels and the changes in clinical symptom scores before and after treatment of the two groups were compared. Results The total effective rate of the observation group was 95.00%, which was significantly higher than that of the control group(70.00%). The difference between the two groups was significant(P<0.05). After treatment, the levels of inflammatory factors TNF-α and IL-10 in the two groups were significantly lower than those before treatment(P<0.05). The levels of TNF-α and IL-10 in the observation group were significantly lower than those in the control group, and the difference between the groups was significant(P<0.05). The clinical symptom score of the observation group was(2.56±0.85)points after treatment,which was significantly different from that of the control group and before treatment(P<0.05). Conclusion Mesalazine combined with bifidobacteria is effective in the treatment of ulcerative colitis, which can inhibit the inflammatory response, and is worthy of clinical promotion and application.
作者
陈烁
陈怡
CHEN Shuo;CHEN Yi(Department of Gastroenterology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine in Zhejiang Province, Wenzhou 325000, China)
出处
《中国现代医生》
2019年第8期40-43,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2017KY629)
