摘要
目的:观察微生态制剂枯草杆菌、肠球菌二联活菌肠溶胶囊对轻、中度溃疡性结肠炎(Ulcerative colitis,UC)的疗效.方法:本研究收集我科2年住院治疗的轻、中度UC患者139例,按随机、对照分为美沙拉嗪治疗组81人与枯草杆菌、肠球菌二联活菌肠溶胶囊+美沙拉嗪治疗组58人,比较两组在达到缓解时间、缓解率、维持缓解时间、复发率等方面的差异,并对结果进行统计学分析.结果:枯草杆菌、肠球菌二联活菌肠溶胶囊+美沙拉嗪与美沙拉嗪相比,两组在缓解率、维持缓解时间、复发率的比较,枯草杆菌、肠球菌二联活菌肠溶胶囊+美沙拉嗪组缓解率、维持缓解时间、复发率方面差异有统计学意义(x2=4.481,F=3.435,x2=4.757,均P<0.05);达到缓解时间的比较,差异无统计学意义(P>0.05).结论:在治疗轻、中度UC中,枯草杆菌、肠球菌二联活菌肠溶胶囊+美沙拉嗪与美沙拉嗪相比,具有缓解率高、维持缓解时间长、复发率低等优点.
AIM： To observe the clinical effects of a micro- ecological preparation comprising Bacillus sub- tilis and Enterococcus in the treatment of mild and moderate ulcerative colitis. METHODS： The clinical data for 139 patients treated with mesalazine, alone or in combina- tion with Bacillus subtilis plus Enterococcus vi- able enteric-coated capsules during the past two years in our hospital, were analyzed and com- pared in terms of the time of clinical remission, clinical remission rate, relapse-free time and re- lapse rate. RESULTS： There were statistical differences between the two groups in clinical remission rate, relapse-free time and relapse rate （;2 = 4.481, F = 3.435, χ^2 = 4.757, all P 〈 0.05）. There was no dif- ference between the two groups in the time of clinical remission （P 〉 0.05）. CONCLUSION： Combined use of Bacillus subti- lis plus Enterococcus viable enteric-coated cap- sules is associated with a higher clinical remis- sion rate, longer relapse-free time, and a lower relapse rate in the treatment of mild and moder- ate active ulcerative colitis.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第19期1796-1799,共4页
World Chinese Journal of Digestology
关键词
微生态制剂
美沙拉嗪
溃疡性结肠炎
Microecological preparation
Mesalazine, Ulcerative colitis
