摘要
目的对妊娠末期B族链球菌(GBS)感染状况与阴道微生态Nugent评分进行相关性分析。方法 2017年10月～2018年8月共收集621例妊娠35～37周孕妇的生殖道分泌物标本,应用荧光定量PCR检测GBS,应用涂片革兰氏染色进行Nugent评分,以GBS结果阳性与否分组,比较两组间Nugent评分差异有无统计学意义,以Nugent评分分组比较组间GBS阳性率差异有无统计学意义,双侧P<0.05为差异有统计学意义。结果 GBS阴性组与阳性组间Nugent评分分别为4.07±1.11,4.66±1.49,差异有统计学意义(t=-3.380,P<0.001)。根据Nugent评分分为正常组(≤3分)、疑似组(4～6分)与细菌性阴道炎(BV)患者组(≥7分),三组GBS阳性率分别为9.14%,11.81%和33.33%。两两比较显示,正常组与疑似组间阳性率差异无统计学意义(χ~2=0.916,P=0.339),正常组与BV组组间比较差异有统计学意义(χ~2=19.665,P<0.001),疑似组与BV组组间比较差异有统计学意义(χ~2=17.689,P<0.001)。结论 GBS感染与阴道微生态紊乱有一定的相关性,Nugent评分越高,GBS感染率越高,有一定的临床提示意义。
Objective To analyze the correlation between the status of group B Streptococcus(GBS)infection and Nugent score in the late pregnancy.Methods 621pregnant women at 35~37weeks of gestation were collected for GBS and Nugent score,and compared the Nugent score between the GBS positive and negative groups,subsequently.According to Nugent score,all participants were divided into three subgroups,and compared the GBS positive rates among the three subgroups.Results The Nugent score between GBS negative positive group was 4.07±1.11vs 4.66±1.49(t=-3.380,P<0.001),respectively.According to Nugent score,the positive rates of GBS were 9.14%,11.81%and 33.33%respectively.The GBS positive rate in bacterial vaginosis(BV)group was the highest among the three subgroups.Conclusion The infection of GBS is correlated with vaginal microecological disturbance.
作者
曹清芸
柏明见
何美琳
侯芳
梁国威
CAO Qing-yun;BAI Ming-jian;HE Mei-lin;HOU Fang;LIANG Guo-wei(Department of Clinical Laboratory,Aerospace Central Hospital,Beijing 100049,China;Department of Pathology,Aerospace Central Hospital,Beijing 100049,China)
出处
《现代检验医学杂志》
CAS
2019年第2期122-124,共3页
Journal of Modern Laboratory Medicine
