摘要
目的:探讨丹红注射液联合达比加群酯预防下肢骨折术后下肢静脉血栓的疗效。方法:选取2017年12月至2018年6月武汉市江夏区中医院收治的拟行下肢骨折术患者176例,以随机数字表法分为观察组和对照组,每组88例。对照组患者口服达比加群酯治疗,观察组患者在对照组的基础上加用丹红注射液治疗。比较两组患者的临床疗效、凝血功能指标水平[血浆凝血酶原时间(PT)、活化部分凝血酶时间(APTT)和D-二聚体(D-D)]、血液流变学指标水平和不良反应发生情况的差异。结果:观察组患者的总有效率为94.32%(83/88),明显高于对照组的76.14%(67/88),差异有统计学意义(P<0.05)。治疗后,两组患者PT和APTT较治疗前明显延长,D-D水平明显降低,且观察组患者上述指标水平明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者全血低切黏度、全血高切黏度、血浆黏度和纤维蛋白原水平较治疗前明显降低,且观察组患者上述指标水平明显优于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率均为5.68%(5/88),差异无统计学意义(P>0.05)。结论:丹红注射液联合达比加群酯可有效减少下肢骨折术后下肢深静脉血栓的发生,改善患者的血液高凝状态,安全有效。
OBJECTIVE:To probe into the efficacy of Danhong injection combined with dabigatran etexilate in preventing lower limb venous thrombosis after surgery of lower limb fracture. METHODS:176 patients undergoing surgery of lower limb fracture admitted into Traditional Chinese Medicine Hospital of Jiangxia District from Dec. 2017 to Jun. 2018 were selected and divided into observation group and control group via random number table, with 88 cases in each group. The control group was treated with dabigatran etexilate, while the observation group was given Danhong injection combined with dabigatran etexilate. Differences in clinical efficacy, coagulation function indices [prothrombin time(PT), activated partial thrombin time(APTT) and D-dimer(D-D)], hemorheology indices and incidences of adverse drug reactions between two groups were compared. RESULTS:The total effective rate of observation group was 94.32%(83/88), which was significantly higher than that of the control group(76.14%, 67/88), with statistically significant difference(P<0.05). After treatment, the PT and APTT levels of both groups had been significantly prolonged, with significantly lower D-D levels, and the above indices of observation group were significantly better than those of the control group, with statistically significant differences(P<0.05). After treatment, the whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity and fibrinogen level of both groups were significantly lower than those of before treatment, and the above indices of observation group were significantly better than the control group, with statistically significant differences(P<0.05). Both of the incidences of adverse drug reactions of both groups were 5.68%(5/88), the difference had no statistical significance(P>0.05). CONCLUSIONS:Danhong injection combined with dabigatran etexilate can effectively reduce the incidences of lower limb venous thrombosis after surgery of lower limb fracture, which can improve hypercoagulable state, with safety and effectiveness.
作者
田志强
杨晓艳
杨光州
TIAN Zhiqiang;YANG Xiaoyan;YANG Guangzhou(Dept.of Pharmacy,Traditional Chinese Medicine Hosj3ital of Jiangxia District,Hubei Wuhan 430200,China;Dept.of Pharmacy,Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Hubei Wuhan 430064,China;Dept.of Orthopedics,Traditional Chinese Medicine Hospital of Jiangxia District,Hubei Wuhan 430200,China)
出处
《中国医院用药评价与分析》
2019年第3期309-311,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
