摘要
目的:比较盐酸米那普仑与氟西汀治疗抑郁症的疗效及安全性。方法:选取2017年11月至2018年4月南阳市第四人民医院收治的抑郁症患者100例,按随机数字表法分为观察组和对照组,每组50例。对照组患者给予氟西汀治疗,观察组患者给予盐酸米那普仑治疗。比较两组患者的临床疗效、汉密尔顿抑郁量表(hamilton depression scale,HAMD)评分、汉密尔顿焦虑量表(hamilton anxiety scale,HAMA)评分、多伦多述情障碍量表评分及不良反应发生情况的差异。结果:观察组、对照组患者的总有效率分别为86.00%(43/50)、82.00%(41/50),差异无统计学意义(P>0.05)。治疗1、2及3个月后,两组患者HAMD、HAMA评分均较治疗前显著降低,差异有统计学意义(P<0.05),但两组间的差异无统计学意义(P>0.05)。治疗后,两组患者外向型思维评分、情感描述不能评分、情感辨别不能评分及总分较治疗前明显降低,差异均有统计学意义(P<0.05),但两组间的差异均无统计学意义(P>0.05)。观察组、对照组患者的不良反应发生率分别为16.00%(8/50)、20.00%(10/50),差异无统计学意义(P>0.05)。结论:盐酸米那普仑与氟西汀治疗抑郁症的疗效相当,且均未增加不良反应,安全性高。
OBJECTIVE: To compare the clinical efficacy and safety between milnacipran hydrochloride and fluoxetine in treatment of depression. METHODS: 100 patients with depression admitted into the Fourth People’s Hospital of Nanyang from Feb. Nov. 2017 to Apr. 2018 were selected and divided into observation group and control group via random number table, with 50 cases in each group. The control group was treated with fluoxetine, while the observation group was given milnacipran hydrochloride. Differences in clinical efficacy, scores of Hamilton Depression Scale(HAMD), scores of Hamilton Anxiety Scale(HAMA), scores of Toronto Alexithymia Scale(TAS-20) and incidences of adverse drug reactions between two groups were compared. RESULTS: The total effective rates of observation group and control group were respectively 86.00%(43/50) and 82.00%(41/50), the difference had no statistical significance(P>0.05). At 1, 2 and 3 months after treatment, the HAMD and HAMA scores of both groups had been significantly decreased, with statistically significant differences(P<0.05), while there was no statistical significance in inter-group comparison(P>0.05). After treatment, the extraverted thinking, emotional description disability, emotional discrimination disability and total score of both groups had been significantly decreased, with statistically significant differences(P<0.05);while no statistical significance in difference between two groups(P>0.05). The incidences of adverse drug reactions of observation group and the control group were respectively 16.00%(8/50) and 20.00%(10/50), the difference had no statistical significance(P>0.05). CONCLUSIONS: The efficacy of milnacipran hydrochloride and fluoxetine in treatment of depression is equivalent, and no adverse drug reactions are increased, with high safety.
作者
潘新华
马秀虎
PAN Xinhua;MA Xiuhu(Dept.of Drug and Equipment,the Fourth People’s Hospital of Nanyang,Henan Nanyang 473000,China;Dept.of Psychiatry,the Fourth People’s Hospital of Nanyang,Henan Nanyang 473000,China)
出处
《中国医院用药评价与分析》
2019年第3期306-308,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
抑郁症
盐酸米那普仑
氟西汀
临床疗效
安全性
Depression
Milnacipran hydrochloride
Fluoxetine
Clinical efficacy
Safety
