摘要
目的:比较蔗糖铁注射液不同给药时间间隔治疗妇科贫血的疗效及安全性。方法:选取2017年1月至2018年6月大连市妇幼保健院收治的妇科贫血患者200例,以随机数字表法分为A组和B组,每组100例。A组患者于第1、2及3日给予蔗糖铁注射液200 mg/d,B组患者于第1、3及5日给予蔗糖铁注射液200 mg/d。两组患者的补铁总量均为600 mg。治疗第7日,比较两组患者的血红蛋白(Hb)、红细胞比容(HCT)和红细胞计数(RBC)水平,临床疗效及不良反应发生情况的差异。结果:治疗后,两组患者的Hb、Hct及RBC水平较治疗前明显升高,差异均有统计学意义(P<0.05);但两组患者上述指标的差异均无统计学意义(P>0.05)。以Hb水平变化计,B组患者的总有效率明显高于A组,差异有统计学意义(P<0.05)。A、B组患者的不良反应发生率分别为5%(5/100)、4%(4/100),差异无统计学意义(P>0.05)。结论:蔗糖铁注射液不同给药时间间隔治疗妇科贫血的疗效及安全性均无显著差异,临床可根据患者情况选择相应的给药方式。
OBJECTIVE: To compare the efficacy and safety of sucrose iron injection at different dosing intervals in treatment of gynecological anemia. METHODS: 200 patients with gynecological anemia admitted into Dalian Maternal and Child Health Hospital from Jan. 2017 to Jun. 2018 were selected and divided into group A and group B via random number table, with 100 cases in each group. Group A was given 200 mg/d of sucrose iron injection at the 1 st, 2 nd and 3 rd days, while group B was given 200 mg/d of sucrose iron injection at the 1 st, 3 rd and 5 th days. The total iron supplementation of both groups were 600 mg. At the 7 th day of treatment, the differences in hemoglobin(Hb), hematocrit(HCT), red blood cell count(RBC), clinical efficacy and incidences of adverse reactions between two groups were compared. RESULTS: After treatment, the Hb, Hct and RBC levels of both groups were significantly higher than those of before treatment, with statistically significant differences(P<0.05);while there were no statistical significance in differences between the two groups(P>0.05). Only according to Hb, The total effective rate of group B was significantly higher than that of group A, with statistically significant differences(P<0.05). The incidences of adverse drug reactions of group A and group B were respectively 5%(5/100) and 4%(4/100), the difference had no statistical significance(P>0.05). CONCLUSIONS: There are no statistical significance in differences in efficacy and safety of sucrose iron injection at different dosing intervals in treatment of gynecological anemia, corresponding administration method can be selected according to the patient’s condition.
作者
吉柳
武文慧
李晓军
阎丽丽
冯九香
JI Liu;WU Wenhui;LI Xiaojun;YAN Lili;FENG Jiuxiang(Dept.of Pharmacy,Dalian Maternal and Child Health Hospital,Liaoning Dalian 116033,China;Dept.of Gynaecology,Dalian Matenaland Child Health Hospital,Liaoning Dalian 116033,China)
出处
《中国医院用药评价与分析》
2019年第3期287-289,293,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
大连市卫计委基金资助项目(No.063)
