摘要
目的:观察肾母细胞瘤患儿Bim、Otc4蛋白表达情况,分析其临床意义。方法:选取2015年2月至2017年8月在我院接受治疗的肾母细胞瘤患儿100例,观察Bim、Otc4蛋白在肾母细胞瘤组织和癌旁正常组织中的表达情况,比较不同临床特征患儿肾母细胞瘤组织中Bim、Otc4蛋白表达的差异,分析影响肾母细胞瘤组织中Bim、Otc4蛋白表达的因素。结果:肾母细胞瘤组织中的Bim、Otc4蛋白阳性表达率高于正常组织(P均<0.01)。肿瘤直径≥5 cm、临床分期为Ⅲ～Ⅳ期、有淋巴结转移的肾母细胞瘤患儿瘤组织中的Bim、Otc4蛋白阳性表达率较高,而不同年龄、性别、肿瘤部位的患儿Bim、Otc4蛋白阳性表达率差异无统计学意义。进一步多因素Logistic回归分析显示,肾母细胞瘤患儿瘤组织中Bim、Otc4蛋白阳性表达率与临床分期和淋巴结转移情况密切相关。结论:肾母细胞瘤患儿瘤组织中Bim、Otc4蛋白阳性表达率较高,且与患儿的临床分期和淋巴结转移情况密切相关。
Objective: To observe the expression of Bim and Otc4 protein in children with nephroblastoma, and to analyze its clinical significance. Methods: Totally 100 children with nephroblastoma admitted into our hospital from Feb. 2015 to Aug. 2017 were selected as the research subjects. The expression of Bim and Otc4 protein in nephroblastoma tissues and paracancerous normal tissues was observed. Differences of expression of Bim and Otc4 protein in nephroblastoma tissues of children with different clinical characteristics were compared, and factors influencing the expression of Bim and Otc4 protein in nephroblastoma tissues were analyzed. Results: The positive expression of Bim, Otc4 protein in nephroblastoma tissues was significantly higher than that in normal tissues (P<0.01). The positive expression of Bim and Otc4 protein in nephroblastoma tissues of children with nephroblastoma with tumor diameter ≥ 5 cm, clinical stage from III to IV and lymph node metastasis was higher, yet there was no significant difference in the positive expression of Bim and Otc4 protein in nephroblastoma tissues of children of different ages, genders and tumor sites. Further multivariate Logistic regression analysis showed that the positive expression rates of Bim and Otc4 protein in nephroblastoma tissues of children with nephroblastoma were closely related to the clinical stage and lymph node metastasis. Conclusion: The positive expression rate of Bim and Otc4 protein in nephroblastoma tissues of children with nephroblastoma is relatively high, and it is closely related to the clinical stage and lymph node metastasis of children.
作者
王利娟
黄闪
张红梅
赵丽颖
李慧霞
Wang Lijuan;Huang Shan;Zhang Hongmei;Zhao Liying;Li Huixia(Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Henan Zhengzhou 450000, China)
出处
《儿科药学杂志》
CAS
2019年第4期1-3,共3页
Journal of Pediatric Pharmacy
关键词
肾母细胞瘤
凋亡
蛋白
影响因素
nephroblastoma
apoptosis
protein
influencing factors
