升阳益肾方联合丙酸氟替卡松气雾剂治疗儿童哮喘并过敏性鼻炎临床研究被引量：7

Clinical Study on Shengyang Yishen Prescription Combined with Fluticasone Propionate Inhaled Aerosol in the Treatment of Children with Asthma Complicated with Allergic Rhinitis

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摘要目的探讨升阳益肾法联合丙酸氟替卡松气雾剂治疗儿童哮喘合并过敏性鼻炎的临床疗效。方法选取医院2016年3月至2018年1月收治的哮喘合并过敏性鼻炎患儿124例,按随机数字表法分为研究组和对照组,各62例。两组患儿均给予丙酸氟替卡松气雾剂治疗,治疗组患儿加用升阳益肾方治疗。结果研究组总有效率为96. 77%,显著高于对照组的82. 26%(P <0. 05);与治疗前比较,两组患儿治疗后的第1秒用力呼气容积(FEV_1)、呼气峰流速(PEF)、呼气高峰流量(PEFR)均显著升高(P <0. 05),超敏C反应蛋白(hs-CRP)、白细胞介素4(IL-4)、肿瘤坏死因子-α(TNF-α)水平均显著降低(P <0. 05),且研究组上述指标均优于对照组(P <0. 05);两组患儿不良反应发生率相当(9. 68%比8. 06%,P> 0. 05)。结论升阳益肾方联合丙酸氟替卡松气雾剂治疗儿童哮喘合并过敏性鼻炎,能有效改善肺功能,下调炎性因子水平。 Objective To investigate the clinical effect of Shengyang Yishen Prescription combined with Fluticasone Propionate Inhaled Aerosol in the treatment of children with asthma complicated with allergic rhinitis.Methods Totally 124 children with asthma complicated with allergic rhinitis admitted to our hospital from March 2016 to January 2018 were selected and randomly divided into the study group and the control group,62 cases in each group.The children patients in the two groups were treated with Fluticasone Propionate Inhaled Aerosol,on this basis,the children patients in the study group were treated with Shengyang Yishen Prescription.Results The total effective rate of the study group was 96.77%,which was significantly higher than 82.26% of the control group(P<0.05).Compared with before treatment,the forced expiratory volume in one second(FEVi),peak expiratory flow(PEF)and peak expiratory flow rate(PEFR)in the two groups were significantly increased after treatment(P<0.05),while the levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-4(IL-4)and tumor necrosis factor-α(TNF-α)were significantly decreased(P<0.05),and the above indexes in the study group were better than those in the control group(P<0.05).The incidence rate of adverse reactions in the two groups was similar(9.68% vs.8.06%,P>0.05).Conclusion Shengyang Yishen Prescription combined with Fluticasone Propionate Inhaled Aerosol in the treatment of children with asthma complicated with allergic rhinitis can effectively improve the lung function and reduce the levels of inflammatory factors.

作者张勤何凡潘菌邬巍 ZHANG Qin;HE Fan;PAN Jun;WU Wei(Shanghai Tenth People's Hospital,Shanghai,China 200072;Fengcheng Hospital of Shanghai Fengxian District,Shanghai,China 201411)

机构地区上海市第十人民医院上海市奉贤区奉城医院

出处《中国药业》 CAS 2019年第8期39-41,共3页 China Pharmaceuticals

基金 2016年度上海市卫生和计划生育委员会科研课题[泸卫计科教〔2016〕15号]

关键词小儿哮喘过敏性鼻炎升阳益肾方丙酸氟替卡松气雾剂临床疗效炎性因子肺功能 children asthma allergic rhinitis Shengyang Yishen Prescription Fluticasone Propionate Inhaled Aerosol clinical effect inflam-matory factors lung function