绝经后女性2型糖尿病伴骨质疏松患者骨密度与骨代谢指标的相关性分析被引量：40

A correlational analysis between bone mineral density and bone metabolic markers in postmenopausal women with osteoporosis and type 2 diabetes mellitus

暂未订购

导出

摘要目的分析研究绝经后女性2型糖尿病伴骨质疏松症患者骨密度与骨代谢指标的相关性。方法选取2013年10月至2017年05月于重庆医科大学附属第一医院内分泌内科住院的绝经后女性2型糖尿病患者385名。搜集其基本资料、骨代谢指标及骨密度等。根据T值将这些患者分为骨质疏松组(233例)、骨量减少组(101例)和骨量正常组(51例),比较三组间骨代谢指标的变化,并对骨密度(bone mineral density,BMD)与各项骨代谢指标进行相关性分析。结果 1型前胶原氨基末端前肽(Type I procollagen N-terminal propeptide,P1NP)、骨钙素(bone Gla protein,BGP)在骨质疏松组显著高于骨量减少组、骨量正常组(P<0.05);随着骨密度的降低,1型胶原羧基端肽β特殊序列(β-Carboxyl terminal peptide,β-CTX)逐渐升高,骨质疏松组、骨量减少组与骨量正常组相比较差异有统计学意义(P<0.05);Spearman等级相关分析示P1NP、BGP、β-CTX与骨密度呈负相关,25(OH)D_3与骨密度呈现正相关。结论绝经后女性2型糖尿病伴骨质疏松症患者骨密度与骨代谢指标有一定的相关性,有助于预测骨折风险并及时抗骨质疏松治疗。 Objective To analyze the correlation between bone mineral density and bone metabolic markers in postmenopausal women with osteoporosis and type 2 diabetes mellitus.Methods A retrospective analysis was made in 385 cases of postmenopausal female patients with type 2 diabetes mellitus,who were admitted to the Department of Endocrinology of the First Affiliated Hospital of Chongqing Medical University from Oct 2013 to May 2017.According to the T scores,the patients were divided into three groups:osteoporosis group(n=233),osteopenic group(n=101),and normal bone mass group(n=51).Data of the general clinical information,bone metabolic markers,and bone mineral density were analyzed to identify the correlation between bone mineral density and bone metabolic markers.Results BGP and P1NP in osteoporosis group were the highest compared to those in osteopenic group and normal bone mass group(P<0.05).Compared to that in the normal bone mass group,the level of β-CTX significantly increased in the osteoporosis group and the osteopenic group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that P1NP,BGP,and β-CTX were negatively correlated with BMD and that 25(OH)D3 was positively correlated with BMD.Conclusion bone metabolic markers is correlated with the BMD in postmenopausal women with osteoporosis and type 2 diabetes mellitus,which can help to predict fracture risk and to treat osteoporosis in time.

作者周婷婷冯正平 ZHOU Tingting;FENG Zhengping(Department of Endocrinology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区重庆医科大学附属第一医院内分泌科

出处《中国骨质疏松杂志》 CAS CSCD 北大核心 2019年第1期29-32,共4页 Chinese Journal of Osteoporosis

关键词 2型糖尿病绝经后女性骨质疏松症骨密度骨代谢生化指标 type 2 diabetes mellitus postmenopausal women osteoporosis bone mineral density bone metabolic markers

分类号 R589.5 [医药卫生—内分泌]

引文网络
相关文献

参考文献2

1原发性骨质疏松症诊治指南(2011年)[J].中华骨质疏松和骨矿盐疾病杂志,2011,4(1):2-17. 被引量：1872
2张萌萌.中国老年学学会骨质疏松委员会骨代谢生化指标临床应用专家共识[J].中国骨质疏松杂志,2014,20(11):1263-1272. 被引量：146

二级参考文献36

1刘忠厚.骨质疏松诊断[M].中国现代文艺出版社,2011:596.
2Lee SK, Lorenzo JA. Parathyroid hormone stimulates TRANCE and inhibits esteopmtegerin messenger ribonucleic acid expresion in mutine bone marrow cultures correlation with osteoelast-like cell formation [ J ]. Endocrinology, 1999, 140 : 3552-3561.
3Kidney Disease: Improving Global Outcomes CKDMBDWG. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney international. Supplement 2009, (113) :S1-130.
4Vesper H. Cosman F. Endres DB, et al. Application of biochemical markers of bone turnover in the assessment and monitoring of bone diseases : approved guidelines. ( 2008 ) NCCLS document C48-A. ISBN 1-56238-539-9.
5Kim CJ. Vitamin D dependent rickets Type I [ J]. Korean J Pediatr,2011,54(2) :51-54.
6Naknsato YR, Janckila A J, Halleen JM, et al. Clinical Significance of immunoasays for type-5 tartrate-resistant acid phosphatase[ J]. Clin Chem. 1999,45 (12) :2150-2157.
7Shiga T, Tsuji Y, Fujioka M, et al. Risk factors for hip fracture in Japanese elderly women with osteoporosis: applicability .of biochemical markers in bone turnover[ J]. Geriatr Gerontol Int, 2009, 9(1): 69-74.
8Bauer DC, Garnero P, Harrison SL, et al. Biochemical markers of bone turnover, hip bone loss, and fracture in older men: the MrOS study[J]. J Bone Miner Res, 2009, 24(12) : 2032-8.
9Donescu OS, BattieMc, Videman T, et al. Anthropometrics and Biochemical markers in men. J Clin Densitom,2005 ,8 :222-227.
10Garnero P, Ferreras M, Karsdal MA, et al. The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation[ J]. Bone Miner Res, 2003, 18 : 859- 867.