摘要
系统评价原花青素的抗氧化损伤效果,为揭示原花青素通过激活Nrf2信号通路拮抗氧化损伤的作用机制提供参考。对CNKI、VIP、Cochrane、Pub Med、Springer等数据库进行文献检索,查找原花青素干预实验动物的文献资料,对文献资料进行Meta分析,以标准化均数差(standard mean difference,SMD)描述组间差别。与氧化损伤模型组比较,原花青素干预组SOD[SMD为2.11,95%CI(1.45,2.78)]、GSH-Px[SMD为2.88,95%CI(1.94,3.82)]、GSH[SMD为4.45,95%CI(3.09,5.81)]、Nrf2[SMD为3.75,95%CI(2.35,5.15)]、NQO1[SMD为4.92,95%CI(0.65,9.19)]、HO-1[SMD为5.13,95%CI(2.01,8.25)]、GST[SMD为4.77,95%CI(2.31,7.22)]水平均高于氧化损伤模型组,差异有统计学意义(P均<0.05);MDA[SMD为-3.00,95%CI(-3.59,-2.41)]水平低于氧化损伤模型组,差异有统计学意义(P<0.05)。原花青素可以通过激活Nrf2信号通路拮抗氧化损伤;亚组分析发现,高剂量、长时间的原花青素干预抗氧化作用更强。
The systematic review was performed to investigate the protective effects of proanthocyanidins on oxidative damage,which provides reference for revealing the mechanism of anti-oxidative damage by activating the Nrf2 signaling pathway.Literature was searched by independently searching databases,including the China National Knowledge Infrastucture,VIP,Wanfang data,CBM,Cochrane,PubMed,Springer,Web of Science to search for the data of intervention on experimental animals of proanthocyanidins.And a meta-analysis was to retrieve experimental data on PC and oxidative damage published both in China and worldwide in the past few years.The difference between groups was described by standard mean difference(SMD).Levels of SOD[SMD=2.11,95%CI(1.45,2.78)],GSH-Px[SMD=2.88,95%CI(1.94,3.82)],GSH[SMD=4.45,95%CI(3.09,5.81)],Nrf2[SMD=3.75,95%CI(2.35,5.15)],NQO1[SMD=4.92,95%CI(0.65,9.19)],HO-1[SMD=5.13,95%CI(2.01,8.25)],GST[SMD=4.77,95%CI(2.31,7.22)]in the PC intervention group was higher than that of the oxidative injured model group(P<0.05).Levels of MDA[SMD=-3.00,95%CI(-3.59,-2.41)]in the PC intervention group was lower than that of the oxidative injured model group(P<0.05).While Nrf2[SMD=2.79,95%CI(0.64,4.94)],HO-1[SMD=2.03,95%CI(0.17,3.89)],GST[SMD=2.23,95%CI(0.42,4.03)]in the PC group was higher than control group(P<0.05).Subgroup analysis demonstrated that intervention time(≥35d or 24h)of PC was found to promote the production of Nrf2(P=0.02);high intervention dose(>200mg/kg or 1mg/L)of PC increase the expression of Nrf2(P=0.04).PC can protect against oxidative damage by activating the Nrf2 signaling pathway.High-dose and long-time intervention of PC can play a better role in antioxidative damage.
作者
冯明富
任庆新
姜云星
李述刚
FENG Ming-fu;REN Qing-xin;JIANG Yun-xing;LI Shu-gang(Department of Preventive Medicine,Shihezi University School of Medicine,Shihezi 832000,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2018年第3期526-533,共8页
Natural Product Research and Development
基金
国家自然科学基金(81760584
81560517)
兵团应用基础研究(2015AG014)
兵团科技领域重点攻关项目(2014BA039)
石河子大学国际合作项目(GJHZ201602)
