摘要
目的探讨冠心病患者的颈动脉内膜厚度(IMT)、血尿酸与斑块不稳定性的关系.方法选择冠状动脉造影确诊冠心病(CHD)患者148例为实验组,按造影结果分为单支、双支和三支病变组;依据WHO诊断标准又分为急性心肌梗死(AMI)、不稳定型心绞痛(UPA)、稳定型心绞痛(SAP)3组;冠脉造影排除CHD的40例为对照组.测定所有患者的血尿酸及颈动脉彩超测定颈动脉内中膜厚度,分析两者与斑块不稳定性、冠脉病变支数及冠脉狭窄程度之间的关系.结果冠心病各组血尿酸水平显著高于对照组(P<0.05);血尿酸水平单支病变组、双支病变组与三支病变组3组间比较差异存在统计学意义(P<0.05);血尿酸与IMT、冠脉Gensini积分之间正相关(r=0.506,P<0.05;r=0.345,P<0.05).结论血尿酸水平、颈动脉内中膜厚度与冠脉病变支数及冠脉病变狭窄程度呈正相关,两者与冠状动脉斑块的不稳定性及冠脉病变严重程度密切相关,有助于临床评估冠心病患者冠状动脉病变严重程度和预测急性冠脉综合征的发生,提高对冠心病的预诊能力.
Objective To study the correlation of serum uric acid and carotid intimal-medial thickness with plaque stability in coronary heart disease(CHD).Method148Patients with CHD who were proved by coronary arterigraphy were selected as the experimental group,and were divided into three subgroups of singlebranch,double-branch and three-branch according to the scope of pathological changes by coronary angiogram.The CHD patients were divided into three subgroups of acute myocardial infarction(AMI),unstable angina pectoris(UAP)and stable angina pector(SAP)according to the WHO standards.40Cases were excluded by coronary arterigraphy as control group.Blood uric acid and carotid artery intima-media thickness of all the patients were measured by carotid ultrasonography,and the correlation of the both with the plaque instability and the coronary lesion branch number with the severity of coronary stenosis were analyzed.Results The serum uric acid level in the different CHD groups was significantly higher than in the control group(P<0.05).There are significant differences in the serum uric acid level among the three groups,single-vessel group,double-vessel group and three-ressel group(P<0.05).The serum uric acid was positively correlated with the IMT and coronary Gensini score(r=0.506,P<0.05;r=0.345,P<0.05).Conclusion Both uric acid and carotid intimal-medial thickness were positively correlated with coronary plaque instability and coronary lesion severity,indicating that the both should be closely related to the instability of coronary plaque and severity of coronary artery lesions in patients with coronary heart disease,which may help to assess the severity of coronary artery lesions and predict the occurrence of acute coronary syndrome to improve the ability of early diagnosis of coronary heart disease.
作者
郭华涛
徐丽华
常哲兴
Guo Huatao;Xu Lihua;Chang Zhexing(Affiliated Hospital of Beihua University,Jilin 132011,China)
出处
《北华大学学报（自然科学版）》
CAS
2017年第6期755-758,共4页
Journal of Beihua University（Natural Science）
基金
吉林省教育厅科学技术研究项目(2012146)
吉林市科技发展计划项目(201233121)
