摘要
目的:观察阿托伐他汀钙、阿司匹林联合血府逐瘀汤治疗颈动脉硬化斑块的疗效。方法:收集2012年3月至2015年12月B超检出的颈动脉硬化斑块患者60例,分为对照组(30例)和观察组(30例)。对照组给予阿托伐他汀钙片(20 mg/d)和阿司匹林肠溶片(0.1 g/d)治疗;观察组在对照组基础上加服中药血府逐瘀汤每日1贴,两组均治疗24周。两组均于治疗24周后行颈动脉超声检查,观察颈动脉内膜厚度(IMT),计算斑块横切面最大面积和颈动脉狭窄率。结果:治疗后观察组的IMT、斑块面积和狭窄率分别为(1.47±0.11)mm、(20.58±1.39)mm^2和35.03%±4.51%,对照组分别为(1.52±0.10)mm、(21.15±1.11)mm^2和40.43%±4.34%,观察组优于对照组(P均<0.05),未发现明显不良反应。结论:中药血府逐瘀汤联合阿托伐他汀钙和阿司匹林在改善IMT斑块面积、颈动脉狭窄率等方面有良好作用。
Objective： To observe the effect of atorvastatin calcium and aspirin combined with Xuefu Zhuyu Decoction in the treatment of carotid atherosclerotic plaque. Methods： From March 2012 to December 2015, 60 patients with carotid atherosclerotic plaques detected by B-mode ultrasonography were collected and divided into a control group （30 cases） and an observation group （30 cases）. The control group was treated with atorvastatin calcium tablets （20 mg/d） and aspirin entericcoated tablets （0.1 g/d）, the observation group was treated with Chinese medicine Xuefu Zhuyu Decoctionl daily on the basis of the control group, and the two groups were treated for 24 weeks. After 24 weeks of treatment, the two groups were examined with cervical artery ultrasound, carotid intima-media thickness （IMT） was observed, and the maximum area of plaque transverse section and the rate of carotid stenosis were calculated. Results： After treatment, the IMT, plaque area and stenosis rate of the observation group were （1.47±0.11） mm, （20.58±1.39） mm^2 and 35.03%＋4.51%, and those of the control group were （1.52±0.10） mm, （21.15±1.11） mm^2 and 40.43%±4.34%. The observation group was better than the control group（P〈0.05）, and no obvious adverse reaction was found. Conclusion： Chinese medicine Xuefu Zhuyu Decoction combined with atorvastatin calcium and aspirin play a good role in improving the plaque area of IMT and the rate of carotid stenosis.
出处
《上海医药》
CAS
2017年第18期20-21,24,共3页
Shanghai Medical & Pharmaceutical Journal
基金
徐汇区医学科技项目(SHXH201238)
