摘要
目的探讨肾癌手术前超声检测彩色血流平均密度(Mean Color Vessel Density,MCVD)与手术后病理组织学分级及微血管密度(Micro Vessel Density,MVD)的相关性。方法对经手术病理确诊的69例肾癌患者术前行超声检查,根据彩色血管能量成像结果,计测MCVD值,术后对肿瘤组织标本进行病理组织学分级,用免疫组化染色法检测MVD值,并对结果进行相关性统计学分析。结果肾癌病灶中MCVD值越高,检测的MVD值也越高,两者呈正相关(r=0.998,P<0.05);术后病理组织学分级Ⅰ~Ⅲ级,各病理组织学分级的MCVD与MVD比较差异均有统计学意义(P<0.05)。结论超声检测肾癌的MCVD值与术后病理组织学分级和MVD值有较好的相关性,而且具有无创伤、可重复性等特点,可作为术前评价肾癌新生血管的可靠方法。对肾癌的早期诊断、治疗及评估预后等均有重要的临床指导意义。
Objective To explore the correlation between preoperative mean color vessel density (MCVD) tested by ultrasound and postoperative histopathological grade in pathology, micro vessel density (MVD) in renal cell carcinoma. Methods 69 cases of renal cell carcinoma patients confirmed via surgical pathology were examined with ultrasound preoperatively, and their MCVD were calculated according to the results of color power angiography. After operation all the slices of tumor tissue specimens were stained with routine hematoxylin-eosin (HE) staining method and immunohistochemistry staining method respectively. The tumor tissue specimens stained by HE were graded in histopothology.Immunohlstochemistry staining was done with instant-type mouse anti-human CD34 monoclonalantibody and used to calculate MVDs. Then MCVD, MVD and histopathological grades were analyzedstatistically. Results As MCVD value was higher in kidney lesion, the detected MVD value increasedmore , both showing positive correlation (r=0.998, P<0.05) in this study. Histopathology was gradedⅠ-Ⅲ after operation. MVD and MCVD in different histopathological grades were different statistically(P<0.05). Conclusion The preoperative MCVD value generated by ultrasound showed good correlation with the postoperative histopathological grade as well as MVD, and ultrasonic detection had the characteristics of no wound, repeatability, which could be used as a reliable method of preoperatively evaluating angiogenesis in renal cell carcinoma. MCVD had important instructive clinical significance to renal cell carcinoma for early diagnosis, treatment and evaluating prognosis, etc.
作者
崔涛
葛明珠
赵燕辉
张延辉
徐涛
刘春雷
CUI Tao;GE Ming-zhu;ZHAO Yan-hui;ZHANG Yan-hui;XU Tao;LIU Chun-lei(Department of Urology Surgery, Qingdao Central Hospital, Qingdao Shandong 266042, China;Department of Abdominal Ultrasonography, Qingdao Tumor Hospital, Qingdao Shandong 266042, China)
出处
《中国医疗设备》
2017年第2期68-70,共3页
China Medical Devices
关键词
超声
彩色血流平均密度
肾肿瘤
微血管密度
病理组织学
ultrasonography
mean color vessel density
kidney neoplasms
micro vessel density
histopathology
