摘要
本文报道了对人类宫颈鳞状上皮癌及小鼠实验性宫颈癌LDH同工酶谱变化的观察结果。20例人类宫颈鳞状上皮癌LDH总活力为对照正常宫颈组织的8倍,LDH同工酶谱的变化是LDH_2及LDH_3减少,LDH_4和LDH_5增加,除LDH_3外,所有变化均具有统计学意义。甲基胆蒽及促癌物黄芫花和乌与甲基胆蒽协同诱发的小鼠实验性宫颈癌LDH的变化是:患宫颈癌小鼠血清及癌组织LDH活力均增高,LDH_5增多,LDH_3、LDH_2和LDH_1减少或缺失,均具统计学意义。LDH同工酶谱总的变化是M亚基增多,H亚基减少。结果如说明宫颈癌组织发生了基因表达失控,是甲基胆蒽所引起,促癌剂加剧了这一变化。
This paper reports on the observation of LDH isozyme patterns in human squamous epithelial and mice experimental cervical carinomas. The activity of LDH in 20 cases of human squamous epithelial cervical cancers is 8 folds higher than normal cervical tissues. The changes of LDH isozyme patterns are as follows: LDH_2 and LDH_3 decrease, LDH_4 and LDH_5 increase. Except LDH_3, all the changes have statistical difference. The changes of LDH in experimental cervical cancer tissue of the mouse with cervical cancer showed increase of LDH and LDH_5 activity and decrease or devoid of LDH_1, LDH_2, LDH_3. All these changes carry statistical insignificance. The overall change of LDH isozyme pattern observed is as follows: M subunits increase. H subunits decrease. The result shows that genetic expression in cancer tissue is out of control and it is induced by MCA and accelerated by promoters.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1991年第5期338-340,346,F002,共5页
Chinese Journal of Clinical Oncology
关键词
宫颈肿瘤
LDH
发病机理
Cervical cancer
LOH isozyme patterns
Pathogenesis
