摘要
用Langendorff离体心脏灌流制备,研究氧自由基清除剂:超氧化物歧化酶(SOD)和亚硒酸钠(Se)对哇巴因所致心脏毒性的影响。研究结果表明SOD(160μ/ml)可延长硅巴因(10^(-6)mol/L)所致室颤发生的时间(P<0.01),但对室早和室速发生的时间无甚影响(均为P>0.05)。Se(2×10^(-5)mol/L)可延长室速(P<0.01)和室颤发生的时间(P<0.01),对室早的发生时间无甚影响(P>0.05);用Se(2×10^(-6)mol/L)对心律失常的发生无甚影响(P>0.05)。本结果提示SOD和Se对离体心脏由哇巴因所诱发的心律失常有不同程度的对抗作用,推测自由基可能参与哇巴因致离体心脏的中毒过程。
The effect of some oxygen free radical scavengers, Superoxide Dismutase (SOD) and Sodium Selenate (Se), on Ouabain induced toxicity of isolated heart were studied by the Langendorff apparatus. The results showed that SOD (160μ/ml) prolonged the time of ventricular fribrillation induced by Ouabain (P<0. 01); Se (2×10^(-5)mol/L) prolonged the times of ventricular tachycardia (P<0.01) and ventricular fibrillation (P<0.01). These suggested that SOD and Se decreased the toxicity of the heart induced by Ouabain in varying degrees. We suggest that the toxicity of Ouabain may be linked to the formation of free radical.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1991年第2期7-11,共5页
Journal of Jinan University(Natural Science & Medicine Edition)
关键词
哇巴因
心脏毒性
氧自由基
清除剂
Superoxide Dismutase, Sodium Selentte, Ouabain, Cardiotoxicity, Free Radical
