摘要
目的:了解血友病甲患者丙型肝炎病毒(HCV)、乙型肝炎病毒(HBV)、艾滋病病毒(HIV)及梅毒的感染情况。方法:对1992年～2000年山东省血液中心确诊和治疗的162例血友病甲患者进行了抗-HCV、HBsAg、丙氨酸氨基转移酶(ALT)、抗-HIV和梅毒抗体血清学检测,并随机选择1000例无偿献血者作为正常对照。结果:162例血友病甲患者抗-HCV、HBsAg和ALT阳性率分别为20.73％(33/162)、4.32％(7/162)和8.64％(14/162);无偿献血者抗-HCV、HBsAg阳性率和ALT异常率分别为3.00％(30/10000)、10.00％(100/1000)和2.00％(20/1000);血友病甲患者和无偿献血者抗-HIV和梅毒抗体阳性率均为0。结论:血友病甲患者抗-HCV阳性率和ALT异常率高于无偿献血者(x^2 分别为 82.04和21.65,P <0.05),BHsAg阳性率低于无偿献血者(x^2=6.72,P <0.05),血友病甲患者和无偿献血者均无HIV和梅毒阳性反应。
Objective: To understand the infection with hepatitis C virus, hepatitis B virus(HBV), human immunodeficiency virus(HIV) and syphilis in hemophilia A patients. Methods: Anti-HCV, HBsAg, ALT, anti-HIV and syphilis in hemophilia A patients during 1992-2000 were analyzed. Random sampling 1 000 volunteer donors was taken as control. Results: In 162 hemophilia A patients investigated, the positive rate of anti-HCV, HBsAg and ALT were 20. 73% , 4. 32% and 8. 64% , respectively. The positive rate of anti-HCV, HBsAg and ALT in 1 000 volunteer donors were 3. 00% , 10. 00% and 2.00% , respectively. The infection of HIV and syphilis hadn' t been found in 162 hemophilia A patients and 1 000 donors. Conclusion: The results revealed that the positive rate of anti-HCV and ALT in hemophilia A patients was higher than that of volunteer donors(P<0.05), but the positive rate of HBsAg in hemophilia A patients was lower than that of volunteer donors(P<0. 05). There wasn't HIV and syphilis population in these hemophilia A patients and volunteer donors.
出处
《血栓与止血学》
2002年第3期115-117,共3页
Chinese Journal of Thrombosis and Hemostasis
