摘要
目的 动态检测正常妊娠、妊娠高血压综合征 (妊高征 )妇女血清瘦素水平的变化特点。方法 采用放射免疫法测定 40例正常非妊娠妇女 (对照组 )以及 5 0例正常妊娠和 14例妊高征妇女(观察组 )孕 16～ 2 0、2 4～ 2 8、3 2～ 3 6周及分娩前的血清瘦素水平及其新生儿的脐血瘦素水平 ,同时测量身高、体重、血压及胎盘重量。结果 ( 1)随着孕周的增加 ,观察组妇女血清瘦素水平呈上升趋势 ,其中妊高征妇女血清瘦素水平为 ( 14 1± 2 2 )～ ( 2 5 4± 2 7) μg/L ,较正常妊娠妇女的 ( 13 4± 3 0 )～( 2 1 4± 3 7) μg/L明显上升 (P <0 0 1) ,并持续至妊娠结束 ,而正常妊娠妇女血清瘦素水平在孕 2 8～3 6周时上升明显 ,孕 2 8周前及孕 3 6周后上升缓慢。 ( 2 )体重、体重指数与血清瘦素水平的相关性分析结果显示 ,正常妊娠、对照组妇女均呈显著性正相关 (r =0 478～ 0 63 9,P <0 0 5或P <0 0 1) ,而妊高征妇女无显著相关性 (r=0 0 3 5～ 0 3 79,P >0 0 5 )。( 3 )收缩压、舒张压、平均动脉压与血清瘦素水平的相关性分析结果显示 ,正常妊娠、孕 2 0周前的妊高征及对照组妇女无显著相关性 (r=0 113～0 498,P >0 0 5 ) ,而妊高征妇女孕 2 0周后呈显著正相关 (r=0 63 9～ 0 85 2 ,P <0 0 5 )
Objective To detect successsively serum leptin levels in normal, pregnancy-induced hypertension(PIH) pregnant women. Methods Levels of serum leptin were measured in the 16-20, 24-28, 32-36 weeks of gestation, at the delivery time in 50 healthy, 14 PIH pregnant women and their newborns and in 40 healthy non-pregnant women by Immuno-radioassay method. Serum leptin levels were correlated with body weight, body mass index (BMI), blood pressure and placental weight. Results (1) The serum leptin levels were increased gradually during the normal (14.1±2.2)-(25.4±2.7) μg/L and the PIH pregnancy [(13.4±3.0)-(21.4±3.7)] μg/L, especially in the PIH women. It was found that leptin concentrations rose markedly from 28 to 36 weeks of gestation, but increased slightly before the 28 weeks of gestation and after the 36 weeks of gestation in normals, and in contrast to the normal pregnancy, consistently higher until to the delivery time in the PIH. (2) The positive correlations were significant between the levels of serum leptin with their body weight and BMI in the normal pregnant and non-pregnant women (r=0.478-0.639,P <0.05 or P <0.01), but not siginificant in the PIH pregnant(r=0.035-0.379,P >0.05). (3) The positive correlations were significant between the serum leptin concentrations and the systolic blood pressure, diastolic blood pressure and mean artory pressure in the PIH women after 20 weeks of gestation(r=0.639-0.852,P <0.05), but not siginificant in the normal pregnant, the PIH before 20 weeks of gestation and the non-pregnant women(r=0.113-0.498,P >0.05).(4)Before the delivery time, the positive correlation between the serum leptin concentrations of the pregnant women and that of the newborns was not significant, and also not significant between the puerperas′ serum leptin levels and the placental weight in the normal pregnant (r=0.132, 0.097, P>0.05). But it was interesting that significantpositive correlation was found between the puerperas′ serum leptin concentrations and the cord serum leptin levels (r=0.792,P <0.01) and significant negative correlation was detected between the puerperas′ serum leptin levels and the placental weight in the PIH women(r=-0.819,P <0.01). (5) The leptin levels of cord blood were positively correlated with the body weight and BMI of newborns in both of the normal and PIH pregnancy (r=0.520-0.655, P <0.05 or P <0.01). Conclusion The characteristic change of serum leptin levels and correlations between the serum leptin concentrations and the related pregnant signs was different in normal and PIH pregnancy.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2002年第9期529-532,共4页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠
妊娠并发症
心血管
高血压
瘦素
妊高征
Pregnancy
Pregnancy complications, cardiovascular
Hypertension
Leptin
