摘要
目的 探讨血清瘦素与高血压、体重指数 (BMI)、能量代谢间的关系。方法 测定 64例男性原发性高血压患者及 5 4例男性正常血压者的血清瘦素浓度、收缩压 (SBP)、舒张压 (DBP)、BMI、血糖 (Glu)、甘油三酯 (TG)、总胆固醇 (TC)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)等指标。血清瘦素用放射免疫法测定。分析瘦素与其它各项参数的相关性。结果 ( 1)两组 ( 118例 )的血清瘦素浓度 ( 3 3± 1 9) μg/L与BMI、SBP、DBP、Glu、TG、TC、LDL等呈显著正相关 (P <0 0 5～P <0 0 0 0 1) ;( 2 )高血压组血清瘦素浓度 ( 3 8± 1 9) μg/L显著高于正常组 ( 2 8± 1 3 ) μg/L(P <0 0 1) ,两组血清瘦素浓度与BMI差异有非常显著意义 (P均 <0 0 0 1)。正常组血清瘦素浓度与SBP显著相关 (P <0 0 5 )。但经协方差分析校正BMI和年龄后 ,两组间血清瘦素浓度差异无显著意义 ;( 3 )在剔除超重、体重过轻、血糖、血脂异常者后 ,高血压组 ( 3 9例 )与正常组 ( 4 0例 )的血清瘦素浓度分别为 [( 3 2± 1 6) μg/L、( 2 8± 1 2 ) μg/L],两者差异无显著意义 ,但仍与BMI显著相关 ,与血压值无显著相关 ;结论 血清瘦素浓度与血压无直接相关关系 ,而与人体肥胖程度有密切关系 ,与能量代谢也可能有关。
Objective To explore the relationship between serum leptin, hypertension, body mass index (BMI) and energy metabolism Methods Serum leptin concentrations were measured by radioimmunoassay Blood pressure (BMI) blood sugar (Glu), triglycerides (TG), total cholesterol (TC)、LDL、HDL、 BUN、Cr and Ur were determined in 64 men with essential hypertension (EHT) and 54 male normotensives (NT) The correlation between leptin and other parameters were analyzed Results (1)Serum leptin concentrations n =118 (3 3±1 9) μg/L in 118 subjects were significantly correlated with SBP、 DBP、 BMI、 Glu、TG、TC and LDL( P <0 05～ P <0 001) (2) Serum leptin concentrations were strongly correlated with BMI in both EHT and NT groups ( P <0 001). The concentration level was significantly higher in EHT group n =64 (3 8±1 9) μg/L than in NT group n =54, (2 8±1 3) μg/L, P <0 01) The difference in serum leptin concentrations between the two groups disappeared when BMI and age were corrected by analysis of covariance In NT group, serum leptin concentrations were correlated with SBP ( P <0 05) (3)If the cases of overweight, underweight, hyperglycemia, hyperglyceridemia were excluded, serum leptin concentrations were still highly correlated with BMI, but no longer related to blood pressure Conclusion serum leptin concentrations are not directly related to blood pressure, but the concentration levels are actually correlated with the degree of obesity and energy metabolism
出处
《中华医学杂志》
CAS
CSCD
北大核心
1999年第9期664-667,共4页
National Medical Journal of China
