摘要
目的 :探讨多种临床因素对乳腺癌患者预后的影响。方法 :对 10 0例乳腺癌患者进行随访 ,统计分析随访资料。结果 :年龄和月经状况对患者预后无显著性影响 ,肿块位置、肿块大小、淋巴结转移、临床分期、复发和激素受体表达等临床因素显著影响患者预后 ,患者 5年生存率有显著性差异。Cox模型多因素分析提示 ,淋巴结转移、临床分期、复发情况及ER表达是独立的预后因素。结论 :早期诊断和治疗以及根据ER表达状况针对性的内分泌治疗是提高术后 5年生存率的关键 。
Objective To study the clinical factors influencing prognosis of breast cancer. Metheds 100 patients of postoperate breast cancer were followed-up for 71.34 months. The data were processed with survival analysis,and multivariate analysis was done with Cox proportional hazard model. Results Lymph node,tumor site,tumor size,TNM clinilal stage, tumor recurrence and expressions of ER and PR were significant factors influencing the prognosis. There was marked difference in 5-year survival rate among the factors,and P values were respectively 0.0012,0.0031,0.0032,0,0,0.0014 and 0.0041. The outcome of Cox model proportional hazard regression indicated Lymph node, TNM clinilal stage,tumor recurrence and expressions of ER were independent prognostic factors. Conclusion Early diagnosis,early operation and endocrine treatment were key factors in improving the prognosis, assessing clinical stage and early finding metastases and recurrence.
出处
《郧阳医学院学报》
2002年第4期207-209,共3页
Journal of Yunyang Medical College
关键词
乳腺癌
预后
COX模型
生存分析
治疗
breast neoplasma
Cox proportional hazard model
prognosis
survival analysis
