摘要
目的:探讨Ⅲ-Ⅳa期鼻咽癌患者不同临床特征及不同治疗模式对鼻咽癌患者预后的影响。方法:对初治进行了根治性放疗的197例Ⅲ-Ⅳa期鼻咽癌患者的临床特征和治疗模式进行回顾性分析。结果:本组患者总的1、3、5年生存率分别为74%、51%、46%,中位生存时间50.6个月;单因素分析显示N分期对预后有显著性影响(P<0.05),多因素分析显示年龄、N分期是影响鼻咽癌生存的独立预后因素(P<0.05);同时接受化疗,联合放化疗组与单纯放疗组比较生存无显著性差异;联合放化疗组中,同期放化疗58例,同期放化疗组与单纯放疗组相比生存无显著性差异;同期放化疗组,基于DDP的同期放化疗34例,羟基喜树碱化疗24例,前者与单纯放疗组预后要好于后者,两两比较均有显著性差异,而前者与单纯放疗组相比,两组的生存无显著性差异。结论:年龄越大,N分期越晚预后越差;放疗联合不规范的化疗未能改善局部晚期鼻咽癌的生存。
Objective：To explore prognostic factors of patients with Ⅲ/Ⅳ stage nasopharyngeal carcinoma（NPC）.Methods：Total of 197 patients with histology-proven NPC and treated with radical radiotherapy for the first time were admitted into our hospital.Prognostic factors such as gender,age,histological type,clinical stage and performance of chemotherapy or not were analyzed.Results：The 1-year,3-year,and 5-year overall survival rates were 74%,51% and 42% respectively.Median time to survival was 50.6 months;Univariate analysis showed that N stage was prognostic factor（P 0.05）.Multivariate analysis showed that age and N stage were the independent prognostic factors for overall survival（P 0.05） ;130 patients were treated with chemoradiotherapy.There was no significant difference in OS between chemoradiotherapy group and radiotherapy alone（RT） group;There were 58 patients treated with concurrent chemoradiotherapy（CRT） among the chemoradiotherapy group.And there was no significant difference in OS between the CRT group and the RT group;There were 34 patients treated with platinum-based chemotherapy and 24 patients treated with HCPT chemotherapy among the CRT group.The OS of the platinum-based CRT group and the RT group was better than the HCPT CRT group.Conclusion：Age and Nstage are prognostic factors for NPC.Time than the young.The later N stage had shorter survival time.Our study failed to demonstrate any significant survival benefit with the addition of irregular chemotherapy for patients with locoregionally advanced NPC.
出处
《现代肿瘤医学》
CAS
2010年第12期2350-2354,共5页
Journal of Modern Oncology
关键词
鼻咽癌
放射治疗
化学治疗
预后因素
nasopharyngeal carcinoma
radiotherapy
chemotherapy
prognostic factors
