摘要
用抗T淋巴细胞及亚群的单克隆抗体(CD系列)检测了50例不同病期的鼻咽癌患者外周血T淋巴细胞及T细胞亚群的变化,结果表明,鼻咽癌T细胞和辅助性T细胞(Th)数减少;抑制性T细胞(Ts)数增加;Th/Ts细胞比值下降,患癌组测定值与正常对照组比较有极显著性差异(p<0.01)。实验结果表明,放射治疗使T细胞总数、辅助性T细胞和抑制性T细胞亦下降,尤以T细胞总数明显下降,表明放射线使细胞免疫功能下降,但通过对鼻咽癌取得局部控制的同时Th/Ts细胞比例失调又有一定程度纠正。结果表明,T细胞及其亚群,尤其Th/Ts比值能较准确地反映机体的免疫状态,对肿瘤临床有一定指导意义。
Using monoclonal antibodies and indirect immunofluorescene stain, the T - lymphocytes and T - cell subsets were analysed in the peripheral blood,in 50 patients with nasopharyngeal carcinoma(NPC) , CD3(Ttotal)
Cells and CD4 cells were reduced, and CD8(Ts)Cells were increased.Furthermore, CD4/CD8 Cell ratio was
Lower than that of normal control group. There was a very significant differnce(p<0. 01). It was suggested that, in the tumou bearing host, immune function was inhibited.
Meanwhile, the immune response of patients with NPC was further reduced after radiotherapy. But, in our experiment, under the control of radiotherapy.
So, the determination of Tcell and T - cell Subsets values can be used for the evaluation of immune state in tumor bearing host in observing of therapy and monitoring tumor recurrence.
出处
《重庆医药》
CSCD
1991年第5期260-262,共3页
