摘要
本文测定94例鼻咽癌、65例喉癌患者血清唾液酸、岩藻糖、前清蛋白(PA)、α_1—抗胰蛋白酶(α_1—AT)、α_1—酸性糖蛋白(α_1—AGP)、触珠蛋白(HP)和转铁蛋白(TF)含量.逐步判别分析法对上述测定项目进行筛选,结果发现:对鼻咽癌、喉癌早期诊断有意义的指标是PA、α_1—AT、α_1—AGP、HP和TF,对治疗后未复发与复发判别有意义的指标是唾液酸,α_1—AT、α_1—AGP和HP;由计算机分别得出早期诊断和判别治疗后有无复发之判别函数式.将本组病例之测定值,分别回代入上述判别函数式,临床诊断与判别结果之符合率均在80%以上.结果表明:血清唾液酸和急相蛋白测定,有助于鼻咽癌。
Serum concentrations of sialic acid, fucose, prealbumin(PA ), α1-antitrypsin (α1-AT), α1-acid glycoproteins(α1-AGP), haptoglobin (HP) and transferrin (TF) were measured in 94 nasopharyngeal carcinoma and 65 cancer of larynx. Statistical evalution was made with stepwise discriminant analysis, and the discriminant functions were obtained. The effectiveness of allocation were examined on every one of all patients in the original data, Our results suggested, with the discriminant function equation consisting of serum PA, α1-AT, α1-AGP, HP and TF concentrations we could best separate the patients sufferng from nasopharyngeal or laryngeal carcinoma from the normal; the effective rate of discriminant was 87.36% and 88% for nasopharyngeal carcinoma from normal and laryngeal carcin-oma from normal respectively. However using discriminant function equation,composed of serum sialic acid, PA and α1-AT, we could also discriminate nasopharyngeal or laryngeal carcinoma with recurrence from the one with non-recurrence, the effective rate of discriminant was 93.1% and 80% for nasopharyngeal carcinoma and cancer of larynx respectively
出处
《重庆医科大学学报》
CAS
CSCD
1991年第4期276-280,共5页
Journal of Chongqing Medical University
关键词
鼻咽肿瘤
喉肿瘤
唾液酸
岩藻糖
Naspoharyngeal carcinoma
Cancer of larynx
Sialic acid
Fucose, Acute phase proteins
