摘要
目的 :研究中药加泼尼松治疗重症肌无力 (MG)的疗效分析和乙酰胆碱受体抗体 (AchRab)的变化。方法 :①采用硫酸蒽酮法对中药制剂进行多糖含量测定。② 132例MG患者随机分为观察组 6 6例采用中药扶正强筋片加泼尼松治疗 ;对照组 6 6例应用泼尼松治疗 ,均观察 3个月。治疗前后进行临床疗效分析和AchRab测定。结果 :①扶正强筋片每片多糖含量不低于 6 .0mg。②临床疗效分析 ,观察组和对照组治疗前后比较差异均有显著性 ,分别P <0 .0 1和P <0 .0 5 ;观察组痊愈和基本痊愈 6 3.6 4 %。对照组 2 7.2 7% ,2组比较差异有显著性 ,P <0 .0 5。结论 :以多糖为指标制定扶正强筋片制剂的质量标准切实可行 ;扶正强筋片加泼尼松治疗MG有较好的协同作用 ,能提高疗效 ,减少泼尼松的用量、疗程和复发。
Objective: To study the quality standard of Fuzhengqiangjinpian and the therapeutic effect of Fuzhengqiangjinpian in combination with prednisone in treating myasthenia gravis (MG) and the changes in AchRab titer. Methods: The polysaccharides of Fuzhengqiangjinpina were measured by Phenol H 2SO 4 method. 132 cases of MG were randomly divided into observation group (Fuzhengqiangjinpian plus prednisone) and control group (prednisone only). Clinical effectiveness and Ach Rab titer before and after treatment were analyzed. Results: Polysaccharide content of Fuzhengqiangjinpian was not less than 6.0 mg each tablet. There was significant difference in the clinical effectiveness in the two groups before and after treatment ( P < 0.01 and P < 0.05 respectively). In the observation group, the curative rate was 63.64% , but that in the control group was 27.27% .Conclusion: It is feasible that the quality standard of Fuzhengqiangjinpian is made by taking polysaccharides as an index. Fuzhengqiangjinpian in combination with prednisone had a better synergic effect in the treatment of MG.
出处
《中国康复》
2002年第3期146-147,共2页
Chinese Journal of Rehabilitation
