摘要
肝癌的临床研究在过去几十年中几乎每十年都有其特征。五十年代由于弄清肝内解剖,使大肝癌的规则性切除成为可能,它使不到10％的肝癌病人受益;六十年代由于免疫学的进步使肝移植问世,它蕴藏着潜在的效益;七十年代由于甲胎蛋白检测用于普查监测,出现了小肝癌的研究,它使另外不到10％的肝癌病人受益,并较大幅度提高了疗效;八十年代以肝动脉栓塞术为代表的肝癌局部治疗兴起,使其中小部分不能切除肝癌转变为可切除,从而又使第三个不到10％的肝癌病人受益。我们预期,九十年代的肝癌临床研究的特征将可概括为“早期、积极、综合、特异”这八个字,而“特异治疗”的研究将可能成为一个主要的趋势。
Due to the clarification of intra-hepatic anatomy in 1950s, regular resection ofliver cancer was realized with <10% patients benefited. In 1960s the advance ofimmunology enabled the liver transplantation to be a potential benefit. The appli-cation of alpha fetoprotein test for mass screening in 1970s made the study ofsmall liver cancer to be possible with another<10% patients benefited. In 1980s,local treatment,represented by embolization of hepatic artery, transformed the un-resectable ones into resectable ones with the third<10% patients benefited. Theauthor expects the clinical study of liver cancer in 1990s will be on the early detec-tion, active and comprehensive treatment, and emphasis of specificity. A detaileddiscussion is given in the paper.
出处
《肿瘤》
CAS
CSCD
北大核心
1991年第2期50-52,共3页
Tumor
