摘要
用内毒素诱导家兔 Shwartzman 反应,观察到血清及肝匀浆过氧化脂质显著增加。热毒清能清除自由基,抑制过氧化脂质生成。文中并对热毒清解毒作用与清除自由基的关系进行了讨论。
The general Shwartzman reactions of rabbits were induced by intravenously injecting endotoxin twice with 24 hours interval.The lipid peroxides (LPO) in sera and liver homogenates of rabbits in normal saline group (12.26±0.84 n mol MDA/ml,1.86±0.43 n mol MDA/mg protein respectively) were significantly higher than those of rabbits in normal control group(7.93±2.90,1.31±0.22,both P<0.01),and LPO in sera and liver homogenates of rabbits in Re-Du-Qing group(6.55±2.97,1.19± 0.12)were evidently lower than those of rabbits in normal saline group(P<0.01),accessed to the LPO level of rabbits in normal control group.In in vitro experiment,LPO of mitochondria in Re-Du-Qing group(1.50±0.43 n mol MDA/mg protein)dramatically decreased,compared with that of endotoxin group(2.39±0.69,P<0.05)and of control group (2.23±0.75,P<0.05).The findings of both in vivo and in vitro experiments showed that Re-Du-Qing possesses scavenging effect on free radicals.In view of the detoxification mechanism of Re-Du-Qing,in addition to inhibiting bacteria and degrading endotoxin,the scavenging effect of Re-Dtt-Qing on free radicals are also included.
出处
《中西医结合杂志》
CAS
CSCD
北大核心
1991年第6期362-363,共2页
关键词
热毒清
内毒素
自由基
过氧化脂质
Re-Du-Qing
endotoxin
free radicals
lipid peroxides
