摘要
目的 探讨载脂蛋白 B、 E基因多态性与高血压、冠心病的相关性。方法 采用聚合酶链反应一限制性片段长度多态性分析 60例正常人、 60例高血压和 2 6例冠心病的载脂蛋白 B、E基因型。结果 高血压组和冠心病组的 Apo B的 Xba I位点等位基因频率高于正常组 ,其中冠心病组与正常组差异明显 ( P<0 .0 5 ) ,Apo E的等位基因 E4高于正常对照组 ( P<0 .0 5和 0 .0 0 5 )。结论 Apo B的 Xba I位点和 Apo E的等位基因 E4是高血压和冠心病的重要遗传标记 。
Objective To explore the relationship of apolipoprotein B and E gene polymorphism with coronary heart disease(CHD)and hypertention.Methods Using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),apolipoprotein B and E gene polymorphism were detected in sixty healthy people(control),sixty patients with hypertention and twenty-six patients with CHD.Results The number of allele apo E4 of apolipoprotein E(apo E) and the number of Xbal of apolipoprotein B were higher in patients with CHD and hypertention than those in the control(P<0 01 and P<0.05,respectively).Conclusions Xbal of apolipoprotein B gene and apo E4 of apolipoprotein E gene might be the genetic markers of CHD and hypertention,therefore the two diseases maybe have congenerous genetic background.
出处
《心脑血管病防治》
2002年第2期20-22,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
