摘要
目的探索形态定量在病理诊断中的新指标。方法将分形几何引入食管癌研究中，应用“分形分析系统”观察人食管癌癌变发生过程中细胞核的改变。结果发现正常上皮、重增上皮和原位癌细胞核的边界分形维数均大于其拓扑维数，即它们是分形结构，并且重增上皮的分维值大于正常上皮（Ｐ＜００１），原位癌又大于重增上皮（Ｐ＜００１）。结论提示分形维数可定量地描述细胞核形态的不规则程度，分形分析对良。
Objective:To find out a new reliable index in pathological morphometry. Methods:Fractal geometry was introduced to research the development of human esophageal carcinoma (HEC). The fractal analysis system (FAS) was used to analize the changes of the nuclear shape during the development process HEC. Results: The fractal dimensions of the nuclear boundary of normal mucosa, atypical hyperplasia and carcinoma in situ (CIS) were significantly greater than their topological dimensions. They were fractal structures. The fractal dimension of atypical hyperplasia was significantly greater than that of normal mucosa and smaller than that of CIS (P<0.01).Conclusion:Fractal dimension analysis is a better way of measuring the extent of nuclearshape irregularity and an useful pathological discriminant index between the malignant and benign cells.
出处
《中国体视学与图像分析》
1999年第1期35-38,共4页
Chinese Journal of Stereology and Image Analysis
关键词
分形几何
分维
食管癌
细胞核
病理诊断
fractal geometry fractal dimension esophageal carcinoma nuclei
