摘要
目的考察胃康宁 (WeiKangNing,WKN)经口给药对胃炎、胃溃疡的防治作用。方法主要以实验性胃炎、胃溃疡动物模型 ,采用灌胃多次给药方法 ,考察WKN对实验性胃炎、胃溃疡动物模型的防治作用。结果WKN对无水乙醇致小鼠胃粘膜损伤有明显保护作用 ,对冰醋酸致痛小鼠有显著镇痛作用 ;能显著抑制大鼠冰醋酸烧灼型胃溃疡的发生 ,对氨水所致大鼠萎缩性胃炎有非常显著的治疗作用 ,并对大鼠胃酸分泌有一定的抑制作用。结论WKN对大、小鼠实验性胃炎、胃溃疡有显著疗效。
Objective To observe and study the prevention and therapeutic effect of the WKN on the peptic ulcer and atrophy gastritis.Methods Mainly adopting peptic ulcer and atrophy gastritis model, investigating the pharmacological effect of the WKN in rats and mice by oral administration. Results The WKN significantly inhibited the gastric mucosal damage induced by absolute alcohol and showed marked analgesic effect on the stomach ache caused by glacial acetic acid in mice. It was also found to inhibit the peptic ulcer induced by glacial acetic acid in rats. In addition,a remarkably therapeutic effect was observed on the atrophy gastritis induced by ammonia in rats and a significant suppressive effect on secreting gastric acid in rats. Conclusions Oral administration of the WKN had a significant prevention and therapeutic effect on the peptic ulcer and the atrophy gastritis.
出处
《沈阳药科大学学报》
CAS
CSCD
2002年第5期344-346,共3页
Journal of Shenyang Pharmaceutical University
