摘要
对75例NIDDM患者红细胞膜脂质成分,空腹血糖、血脂、血浆脂蛋白进行测定,以探讨红细胞膜脂质成分改变与高血糖、高血脂及血浆脂蛋白的关系。结果表明:NIDDM组红细胞膜胆固醇,胆固醇/磷脂比值、过氧化脂质明显高于正常对照组;膜磷脂低于正常对照组;血糖、血脂良好控制的NIDDM患者红细胞膜脂质成分与正常对照组差异无显著性;直线相关分析显示红细胞膜成分改变与高血糖,高血脂及血浆脂蛋白水平存在明显相关性。提示NIDDM患者严重代谢紊乱与红细胞膜脂质成分改变密切有关。
Changes in composition of erythrocyte membrane and plasma lipid in 75 non-insulin-dependent diabetes mellitus (NIDDM) were investigated. The total cholesterol content and malonylolialdehyde (MDA) level of the erythrocyte membrane were significantly increased in NIDDM subjects, the total phospholipid was decreased and the cholesterol/ phospholipid ratio was increased. The changes in composition of erythrocyte membrane lipid correlated with hyper-
glycemia, hypercholesterolemia, hypertriglyceridemia, HDL-C, HDL2C, LDL-C. The results suggested that changes in the composition of plasma lipid may contribute to the alterations of erythrocyte membrane lipid.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1991年第2期71-73,共3页
Chinese Journal of Endocrinology and Metabolism
