摘要
睡眠障碍中非快速眼动睡眠(NREMS)异常与多种涉及睡眠模式异常的病理状态间具有显著的双向相关性,目前尚没有针对睡眠障碍中NREMS异常的特效治疗手段,但针刺治疗本病已显示出一定的疗效。该文从中枢神经系统NREMS相关靶基点出发,认为针刺可能通过调节机体褪黑素水平及睡眠-觉醒昼夜节律、选择性拮抗脑干中缝5-HT能神经元5-HT_(2A)受体、减少下丘脑室旁核CRH及CRH-R_1受体表达及降低大脑微血管壁Ab沉积,调节NREMS,进而改善睡眠障碍中NREMS异常。
Abnormal non-rapid-eye-movement sleep （NREMS） has a significant bidirectional correlation with manifold pathological states involving abnormal sleep modes. At present there is no specific treatment for abnormal NREMS in sleep disorders, but it has been showed that acupuncture has a certain therapeutic effect on this disease. This article considers, from NREMS-related target points in the central nervous system, that acupuncture improves abnormal NREMS in dyssomnia through regulating bodily melatonin levels and the circadian sleep-wake rhythm, selectively antagonizing 5-HT2A receptors on 5-HT neurons in the brainstem raphe, decreasing the expressions of CRH and CRH-R1 receptors in the hypothalamic paraventricular nucleus, reducing A？ deposition in cerebral microvascular walls and adjusting NREMS.
作者
张杨
赵逸彬
焦俊玥
张江松
林咸明
ZHANG Yang;ZHAO Yi-bin;JIAO Jun-yue;ZHANG Jiang-song;LIN Xian-ming(Zhejiang University of Traditional Chinese Medicine Third School of Clinical Medicine,Hangzhou 310053,China;Zhejiang University of Traditional Chinese Medicine Institute of Acupuncture and Neurobiology,Hangzhou 310053,China)
出处
《上海针灸杂志》
2018年第12期1457-1461,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
"十三五"浙江省中医药(中西医结合)重点学科建设计划(2017-XK-A18)
浙江省重点科技创新团队(2013TD15)
