摘要
目的:探讨硫辛酸对糖尿病周围神经病变氧化应激及感觉神经亚群受损的应用效果。方法:选择2017年1月~2018年7月本院收治的糖尿病周围神经病变患者150例,将所有患者随机分为2组,各75例。对照组予以血栓通、胰激肽原酶等药物治疗,观察组在对照组基础上予以硫辛酸治疗,比较两组神经传导速度、血压与血糖水平、血脂指标及血清炎症因子水平。结果:观察组5、250、2 000Hz时双侧正中神经-尺神经、双侧腓浅神经-腓深神经电流感觉阈值(current perception threshold,CPT)值低于对照组,差异具有统计学意义(P<0.05)。治疗后观察组超氧化物歧化酶(SOD)高于对照组,丙二醛(MDA)、超敏C反应蛋白(Hs-CRP)低于对照组,差异有统计学意义(P<0.05)。治疗后观察组患者血压、血糖水平均低于对照组,差异有统计学意义(P<0.05)。治疗后观察组低密度脂蛋白胆固醇(LDLC)、总胆固醇(TC)、甘油三酯(TG)均低于对照组,高密度脂蛋白胆固醇(HDL-C)高于对照组,差异有统计学意义(P<0.05)。结论:给予2型糖尿病患者硫辛酸治疗能够有效改善其血糖、血压及血脂水平,提高神经传导速度,进而减少神经亚群受损程度,有利于提高临床治疗效果。
Objective： To explore the effect of lipoic acid on oxidative stress and damages to sensory nerve subgroups in patients with diabetic peripheral neuropathy. Methods： A total of 150 patients with diabetic peripheral neuropathy who had received treatment in our Hospital between January 2017 and July 2018 were selected. The patients were randomly divided into two groups, with 75 cases in each group. The control group was treated with Xueshuangtong Injection and Kallikrein, and the observation group was treated with lipoic acid plus medicines given to the control group. The nerve conduction velocity, blood pressure and blood glucose, serum lipids, and serum inflammatory factors were compared between the two groups. Results： The CPT values of the median nerve-ulnar nerves, bilateral superficial peroneal nerves and deep peroneal nerves in the observation group at 5 Hz, 250 Hz, and 2 000 Hz were significantly lower than those in the control group （ P 〈0.05）. After treatment, the SOD and HDL-C in the observation group were significantly higher than that in the control group, and MDA, Hs-CRP, levels of blood pressure and blood glucose, LDL-C, TC, and TG were significantly lower than those in the control group （ P 〈0.05）. Conclusion： For patients with type 2 diabetes, lipoic acid can improve the levels of blood glucose, blood pressure and blood lipid, increase nerve conduction velocity, and reduce the damage to sensory nerve subgroup to improve clinical treatment efficacy.
作者
苏冠明
胡淑国
王丽慧
SU Guan-ming;HU Shu-guo;WANG Li-hui(Department of Endocrinology,The Second Hospital of Shijiazhuang,Shijiazhuang 050000,China)
出处
《海南医学院学报》
CAS
2018年第21期1898-1901,共4页
Journal of Hainan Medical University
基金
河北省医学科学研究重点课题(20150874)~~
关键词
2型糖尿病
硫辛酸
感觉神经亚群受损
血糖
血压
Type 2 diabetes
Lipoic acid
Damages to sensory nerve subgroup
Blood glucose
Blood pressure
